UniProt: A0A1B8SHB7

Database: UniProt
Entry: A0A1B8SHB7_9MYCO

LinkDB:  A0A1B8SHB7_9MYCO 
Original site:  A0A1B8SHB7_9MYCO

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (10)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (19)   

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ID   A0A1B8SHB7_9MYCO        Unreviewed;       378 AA.
AC   A0A1B8SHB7;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein {ECO:0000313|EMBL:OBY32115.1};
DE            EC=4.2.1.75 {ECO:0000313|EMBL:OBY32115.1};
DE   SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:ORA80123.1};
GN   ORFNames=ACT18_09100 {ECO:0000313|EMBL:OBY32115.1}, BST28_10335
GN   {ECO:0000313|EMBL:ORA80123.1};
OS   Mycolicibacter kumamotonensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacter.
OX   NCBI_TaxID=354243 {ECO:0000313|EMBL:OBY32115.1, ECO:0000313|Proteomes:UP000092668};
RN   [1] {ECO:0000313|EMBL:OBY32115.1, ECO:0000313|Proteomes:UP000092668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Roo {ECO:0000313|EMBL:OBY32115.1,
RC   ECO:0000313|Proteomes:UP000092668};
RA   Greninger A.L., Cunningham G., Miller S.;
RT   "Genome sequence of Mycobacterium kumamotonense strain Roo.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ORA80123.1, ECO:0000313|Proteomes:UP000192713}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45093 {ECO:0000313|EMBL:ORA80123.1,
RC   ECO:0000313|Proteomes:UP000192713};
RA   Tortoli E., Trovato A., Cirillo D.M.;
RT   "The new phylogeny of genus Mycobacterium.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBY32115.1}.
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DR   EMBL; LFOE01000009; OBY32115.1; -; Genomic_DNA.
DR   EMBL; MVHU01000012; ORA80123.1; -; Genomic_DNA.
DR   RefSeq; WP_019734896.1; NZ_MVHU01000012.1.
DR   AlphaFoldDB; A0A1B8SHB7; -.
DR   STRING; 354243.BST28_10335; -.
DR   PATRIC; fig|354243.3.peg.1891; -.
DR   OrthoDB; 213853at2; -.
DR   Proteomes; UP000092668; Unassembled WGS sequence.
DR   Proteomes; UP000192713; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR039793; UROS/Hem4.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR   PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW   Lyase {ECO:0000313|EMBL:OBY32115.1}.
FT   DOMAIN          281..374
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51755"
FT   DNA_BIND        281..374
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   378 AA;  40521 MW;  8B0A5C0844702675 CRC64;
     MSRLNQTPLS GYRVAVTSSR RADELCAMLR RHGATVCAAP AIAMIDLTDD DELHRRTEEL
     IAEPPDILVV TTAIGFRGWI AAAEGWGLVD ELIEALRSAR IVARGPKAVG ALRAAGLPEE
     WSPQSESSSA MLGYLMQENI TGCRIAVQLH GSTSGCDPIP ELLDQLRYAG ADVVPIRVYR
     WQAARPGGEF DQLTAEIAQR QFDAVSFTSA AAVLATLMRA TELGLSDELL EALRSDVHAM
     CVGPVTARPL AVLGVPTSSP RRMRLGALAR HIVDQLPRLR THTVYAAGHR IEIRSSCVMV
     DGVAKSLSPA GMATLRVLAH HPGRVVSRDD LLDALPGNGS NTHAVETAVL RLRTSLGDKN
     IVATVVKRGY RLAVDSAG
//

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