ID A0A1B8SI99_9MYCO Unreviewed; 1513 AA.
AC A0A1B8SI99;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Haloacid dehalogenase {ECO:0000313|EMBL:OBY32447.1};
GN ORFNames=ACT18_06495 {ECO:0000313|EMBL:OBY32447.1}, BST28_05990
GN {ECO:0000313|EMBL:ORA81544.1};
OS Mycolicibacter kumamotonensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacter.
OX NCBI_TaxID=354243 {ECO:0000313|EMBL:OBY32447.1, ECO:0000313|Proteomes:UP000092668};
RN [1] {ECO:0000313|EMBL:OBY32447.1, ECO:0000313|Proteomes:UP000092668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Roo {ECO:0000313|EMBL:OBY32447.1,
RC ECO:0000313|Proteomes:UP000092668};
RA Greninger A.L., Cunningham G., Miller S.;
RT "Genome sequence of Mycobacterium kumamotonense strain Roo.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORA81544.1, ECO:0000313|Proteomes:UP000192713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45093 {ECO:0000313|EMBL:ORA81544.1,
RC ECO:0000313|Proteomes:UP000192713};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001836};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OBY32447.1}.
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DR EMBL; LFOE01000006; OBY32447.1; -; Genomic_DNA.
DR EMBL; MVHU01000006; ORA81544.1; -; Genomic_DNA.
DR RefSeq; WP_065287556.1; NZ_MVHU01000006.1.
DR STRING; 354243.BST28_05990; -.
DR PATRIC; fig|354243.3.peg.1356; -.
DR OrthoDB; 9814270at2; -.
DR Proteomes; UP000092668; Unassembled WGS sequence.
DR Proteomes; UP000192713; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR42861:SF31; PLASMA MEMBRANE ATPASE-RELATED; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 53..120
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 1451..1513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1513 AA; 155753 MW; 6D87FCF388A8C7F2 CRC64;
MDVFSLGRSG LDAVGTILEA SLDLAAVPLR EGAKILAGER SDLTSRRTWR GAGRAWIEVR
GLDEPGGDIG PAVLDALQNR PGVSSVRLNR PLSRVIVEID DDTSLADLCA AVEAVEKDTE
LSATETAALP GDGLLLAAKG AMLGANAVGL AIATVGSAMR LPAAPKIFDA AASVARYQPL
VRSLLERQIG PARTDAVLSL ASLGAHVITL SPAILAVDMM VEGLKAAETR AGALAWNRYE
PELARWLFSH DDHPDVYSTA RPVPRPAGAA ERHLKRSALA QVVGAGVVGG LTRNLDMTSS
AILATSPKAV RTSCEAFAAT LGQGLADGHA VLPLRPDGLR RLDKIDTVVI DPRVLTGEQR
RVVQIRGAGE HELPQAWNSA QSLLDKPGLR PGWHRVPRMT ARAGRKDPVE ALILPAHHAL
ASAVVLEGRA SGAELVTVDT EILGELRPGF DDIRPLTGEA DTDDVDAALA AAVTDLQQAG
RTVAVLSTAA AQALAAADLA LGVMPTSEST DAAPPFYADL LLADLAGAWQ LLRALPAARA
ATERGVAISI GASSIAGLLL VRGVRATIPG VGARPSRGPG PVTVGAGAGM LSGYLLARRV
LRARAPQPAP AYEWHAMTVE QARELLVPDA VTPLDQRAPV ATASQGMFWP YVHAVREELS
DPMTPILALC SAATAMLGSP IDAVMVGTVL TGNAMLAAYQ RLRAESRLNI LLAQQAPPAR
VVVTGADGTT TYREIVAEQL LPGDLIEVRS NEVVPADARV IEVSDVEVDE SSLTGESLSV
GKQLEPTPGA ELAERSSMLY AGTTVIAGKA LAMVTAVGAD TQTRRASELA SGELPEVGLQ
HHLSQLMYRT FPYSAAGGVA VGALGLLRQG GLRIALGNAI AVAIAAVPEG MPLMATLAQH
ASSQRLSKSG ALVRIPRSVE ALGRVDVVCF DKTGTLSENR LRVTTVRPLR GYTDDDVLGV
AAQAAPAPDG AAHAHATDQA IVEGAAAAAG ARPWAEPDAH LPFRSGRAFS ASVLGSELLV
KGAPEVVLEA CDNAGAEEEQ QVAAMAAQGL RVIAVAQGKL TAAQVRAVRE DSDRLVEVSA
SGLTLIGFLG LADTPRADAP KLLADLTARG VDIRMITGDH PITATAIAAE MGVTVDDEQV
ITGSEWNALN RKEQERVVCE RVIFARMSPE NKVQIVQTLE RAGRVSAMVG DGANDAAAIR
AATVGLGVVA HGSDSAHATA DVVLTDGKIG SLIDAIDEGR RLWKGVQLAI SGLLGGNAGE
VIFSVIGTAV TGNSPLNTRQ LLLMNTLTDA LPATAVAVST PAGPIGGAVR GLDERKLWRA
VAFRGGVTAA AGTAAWAMAS LTGLPGSSQR ASTVALISLV STELGQTVVD SRAPLVLLTA
AGSFAVFAAM VTTPGVSQLL GCTPVGPIGW AQALGTAAAA TTAVAVASRF SAPAEENSGP
VADLVEAATP NKAPAATKTP AQKAVAAKKA PAKKAPAAKK TPAKKVPAKT TAAAKKKGKK
ASAKKPAKLE LVR
//
