ID   A0A1B8UWP0_9BACL        Unreviewed;       410 AA.
AC   A0A1B8UWP0;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=3-hydroxy-3-methylglutaryl-ACP synthase {ECO:0000313|EMBL:OBY80708.1};
GN   ORFNames=BBG47_04995 {ECO:0000313|EMBL:OBY80708.1};
OS   Paenibacillus sp. KS1.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1849249 {ECO:0000313|EMBL:OBY80708.1, ECO:0000313|Proteomes:UP000092663};
RN   [1] {ECO:0000313|EMBL:OBY80708.1, ECO:0000313|Proteomes:UP000092663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KS1 {ECO:0000313|EMBL:OBY80708.1,
RC   ECO:0000313|Proteomes:UP000092663};
RA   Lata P., Govindarajan S., Qi F., Li J.-L., Sahoo M.K.;
RT   "Deep sequencing identified Paenibacillus in Kanamycin resistant culture
RT   isolate from epiphyte Tillandsia usneoides (Spanish moss) in central
RT   Florida, USA.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OBY80708.1}.
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DR   EMBL; MAIS01000009; OBY80708.1; -; Genomic_DNA.
DR   RefSeq; WP_065290801.1; NZ_MAIS01000009.1.
DR   AlphaFoldDB; A0A1B8UWP0; -.
DR   OrthoDB; 9769523at2; -.
DR   Proteomes; UP000092663; Unassembled WGS sequence.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000092663}.
FT   DOMAIN          2..168
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01154"
FT   DOMAIN          269..364
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
SQ   SEQUENCE   410 AA;  46008 MW;  F605AE975799B9D3 CRC64;
     MKVGIEAINF FGGSACIDVR SIFEKRGLDS GRYDNLMLDV KSVAIPCEDP VTNAVNAAKP
     LVDRLSDKEK ESIDLLITTT ESGIDFGKSI STYVHDYLSL SRNCRVFELK QACYGGTAAL
     QMAASYIVAS CLPGRKALVI ATDMAKMSED MDYFEASQGV GAVAMLISDR PDIMELDLGA
     SGYYSFEVMD TCRPLPDMET GDSDLSLLSY LDCFEQCFRD YEAKVEEVDF LTTFDSLAFH
     SPFGGMVKGA HRKLMRELYR ATSEEIECDF QTRVMPSLTY CSKVGNVYSA SLYLSLCSLI
     EYTAIHEEKR IGLFSYGSGC SSEFFSGLVG SGSKQKLMEM NIEQLLSKRH KLSIDEYEPL
     LLLNKEIPFG TRNHRVAFDD FNTIYSHFYK GSGLLVLHEI NEYHREYRWS
//