ID A0A1B8ZGQ1_9FLAO Unreviewed; 442 AA.
AC A0A1B8ZGQ1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN ORFNames=BBI01_12285 {ECO:0000313|EMBL:OCA70716.1};
OS Chryseobacterium artocarpi.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=1414727 {ECO:0000313|EMBL:OCA70716.1, ECO:0000313|Proteomes:UP000092651};
RN [1] {ECO:0000313|Proteomes:UP000092651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTM-3 {ECO:0000313|Proteomes:UP000092651};
RA Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.88;
CC Evidence={ECO:0000256|RuleBase:RU361219};
CC -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate degradation;
CC (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.
CC {ECO:0000256|RuleBase:RU361219}.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCA70716.1}.
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DR EMBL; MAYH01000034; OCA70716.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8ZGQ1; -.
DR OrthoDB; 9764892at2; -.
DR UniPathway; UPA00257; UER00367.
DR Proteomes; UP000092651; Unassembled WGS sequence.
DR GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR Gene3D; 1.10.8.660; -; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|RuleBase:RU361219};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361219}.
SQ SEQUENCE 442 AA; 49651 MW; 41F73C2D75B55249 CRC64;
MNHKPIEGFS KLPKQGKIDW LVNEYLEGNQ EYQNILKQYW NENADLQKLH EEFSENTISN
FYMPYGIAPN FLIDGKLLAL PMAVEESSVV AAASKAAKFW IDKGGFKTTI INTEKLGHTH
FMFSVEPHKL LHFFNFSLKK KLLESTEEIT ANMRKRGGGI LNISLVDKTA EMPNYYQLKA
SFDTVDSMGA NFINSCLEQF GKTLRQEVAT SEDFTQEEKN SLQIVMNILS NFTPDCIVRA
EVSCKMEDLK DDSGISPEEF ASKFKQAVTI AEIEPYRATT HNKGVMNGVD AVVIATGNDF
RATEACAHAY AARDGQYRSL THCTTDNGVF RFWIDLPISV GVVGGLTNLH PLVKFSLALL
GKPSAQELMS ILAVSGLAQN FAALRSLVTT GIQKGHMKMH LLNILNQLGA TEEEKQHFVT
YFKDKTVSHH EVINEFNRMR EK
//
