ID   A0A1B8ZLD8_9FLAO        Unreviewed;       797 AA.
AC   A0A1B8ZLD8;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OCA72380.1};
GN   ORFNames=BBI01_09640 {ECO:0000313|EMBL:OCA72380.1};
OS   Chryseobacterium artocarpi.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Chryseobacterium group; Chryseobacterium.
OX   NCBI_TaxID=1414727 {ECO:0000313|EMBL:OCA72380.1, ECO:0000313|Proteomes:UP000092651};
RN   [1] {ECO:0000313|Proteomes:UP000092651}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTM-3 {ECO:0000313|Proteomes:UP000092651};
RA   Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OCA72380.1}.
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DR   EMBL; MAYH01000023; OCA72380.1; -; Genomic_DNA.
DR   RefSeq; WP_065394604.1; NZ_MAYH01000023.1.
DR   AlphaFoldDB; A0A1B8ZLD8; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000092651; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}.
FT   DOMAIN          7..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..308
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   797 AA;  88410 MW;  8B60E38BD59D37B2 CRC64;
     MKRRIKHVTV LGSGIMGSGI AAHFANIGVE VSLLDIVPFE LTEAEQKKGL TKEDKAVRNR
     IATENFEKLK KSSPALLYSP KFADRIKVGN FDDDLQKIKN TDWIIEVVVE RLDIKKSVYE
     KIEQFRKPGT LISSNTSGIP IHLLTEGRSE DFKKYFAGTH FFNPVRYLPL LEIIPTNDTD
     PEIIDFYMNY GAKFLGKTTV LAKDTPAFIA NRIGVFSMMD LLHNVQKLGL TVSEVDKLTG
     PVIGRPKSAT FRTADVVGLD TLVMVANGVR QSGAEANDFN DVFALPDYIQ KMMDNKWLGS
     KTEQGFYKKV KNAEGKSEIH GLNLDTLEYE LQGKSSFPTL ELTKAIDKPI DRFKVLIGGK
     DKAGELYRKS LGALFAYVSH KVPEISDEVY KIDDAMRAGF GWENGPFEIW DAVGVQKGIE
     LAKDAGYEVS DWVKNVETFY KVNEEGQSIY VDKNSGEYNK IPGQDAFIIL DNIRKNKTLW
     SNSGAAILDL GDGIINFEIR SKMNSLGGEV LDGLNRAIDL AEKEYDGLVV GNQGANFSVG
     ANLAMILMMA IEQDWDDLNM AIAYFQKSMM RVRYSSIPVV VAPHGMTLGG GCEMTMHADR
     VVAAAETYIG LVETGVGVIP GGGGTKELTL RTSREFHSDD VKNNRLRDAF MNIAMGKVAT
     SAYEAYDMGI LEKGKDIVSV SKNRQIAEAK KVAKLLAEQG YTQPIEQKVK VLGKDALGMF
     YVGTDQMLTG NYISAHDKKI ADKLANVMVG GNLSEPTVVT EQYLLNLERE TFLQLCGERK
     TLERIQYMLQ NGKPLRN
//