UniProt: A0A1B9DS86

Database: UniProt
Entry: A0A1B9DS86_9FLAO

LinkDB:  A0A1B9DS86_9FLAO 
Original site:  A0A1B9DS86_9FLAO

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (12)   
   InterPro (8)   
   Pfam (3)   
   SMART (1)   
All databases (21)   

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ID   A0A1B9DS86_9FLAO        Unreviewed;       344 AA.
AC   A0A1B9DS86;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Adenine DNA glycosylase {ECO:0000256|ARBA:ARBA00022023, ECO:0000256|RuleBase:RU365096};
DE            EC=3.2.2.31 {ECO:0000256|ARBA:ARBA00012045, ECO:0000256|RuleBase:RU365096};
GN   Name=mutY {ECO:0000313|EMBL:GEL10032.1};
GN   ORFNames=FBGL_07815 {ECO:0000313|EMBL:OCB72538.1}, FGL01_07710
GN   {ECO:0000313|EMBL:GEL10032.1};
OS   Flavobacterium glycines.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=551990 {ECO:0000313|EMBL:OCB72538.1, ECO:0000313|Proteomes:UP000093226};
RN   [1] {ECO:0000313|Proteomes:UP000093226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 105008 {ECO:0000313|Proteomes:UP000093226};
RA   Shin S.-K., Yi H.;
RT   "Draft genome sequence of Paenibacillus glacialis DSM 22343.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OCB72538.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 105008 {ECO:0000313|EMBL:OCB72538.1};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:GEL10032.1, ECO:0000313|Proteomes:UP000321579}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 105008 {ECO:0000313|EMBL:GEL10032.1,
RC   ECO:0000313|Proteomes:UP000321579};
RA   Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT   "Whole genome shotgun sequence of Flavobacterium glycines NBRC 105008.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adenine glycosylase active on G-A mispairs.
CC       {ECO:0000256|RuleBase:RU365096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC         oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC         apurinic site.; EC=3.2.2.31; Evidence={ECO:0000256|ARBA:ARBA00000843,
CC         ECO:0000256|RuleBase:RU365096};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU365096};
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
CC       {ECO:0000256|ARBA:ARBA00008343, ECO:0000256|RuleBase:RU365096}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OCB72538.1}.
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DR   EMBL; BJVF01000001; GEL10032.1; -; Genomic_DNA.
DR   EMBL; LVEO01000013; OCB72538.1; -; Genomic_DNA.
DR   RefSeq; WP_066327285.1; NZ_LVEO01000013.1.
DR   AlphaFoldDB; A0A1B9DS86; -.
DR   STRING; 551990.SAMN05192550_0948; -.
DR   OrthoDB; 9802365at2; -.
DR   Proteomes; UP000093226; Unassembled WGS sequence.
DR   Proteomes; UP000321579; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000701; F:purine-specific mismatch base pair DNA N-glycosylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd03431; DNA_Glycosylase_C; 1.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR   Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR   InterPro; IPR005760; A/G_AdeGlyc_MutY.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HhH_base_excis_C.
DR   InterPro; IPR000445; HhH_motif.
DR   InterPro; IPR044298; MIG/MutY.
DR   InterPro; IPR029119; MutY_C.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   NCBIfam; TIGR01084; mutY; 1.
DR   PANTHER; PTHR42944; ADENINE DNA GLYCOSYLASE; 1.
DR   PANTHER; PTHR42944:SF1; ADENINE DNA GLYCOSYLASE; 1.
DR   Pfam; PF00633; HHH; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF14815; NUDIX_4; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
DR   SUPFAM; SSF55811; Nudix; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU365096};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU365096};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU365096};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT   DOMAIN          35..186
FT                   /note="HhH-GPD"
FT                   /evidence="ECO:0000259|SMART:SM00478"
SQ   SEQUENCE   344 AA;  39703 MW;  FC5765DAA6630444 CRC64;
     MVFYNLLIAW YLQNKRDLPW RNTTNPYLIW LSEIMLQQTR VAQGLPYFLS FTEAFPTVFD
     LAKADEEKVL KLWQGLGYYS RARNLHKTAQ YIATELNGVF PDNYKELLQL KGVGEYTAAA
     IASFSYNEAV PVVDGNVFRV LARYFDIETD IALASAKKEF ATLAFELMPK DRPAIFNQAI
     MEFGALHCVP KNPDCGSCVF NTSCAALQKK KVDQLPVKLK KLKIKNRYFN YIMLSDAEEK
     TLIQKRTSKG IWHNLYEFPL IETDKEEDFE FVSNAVQQES FFANPIISMR ACNEKSIVHK
     LSHQHLHIKF WKLNVGGEVE NGITKEELKQ FPFPIVIHNF IESN
//

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