ID A0A1B9ENG4_9ACTN Unreviewed; 529 AA.
AC A0A1B9ENG4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=K(+)/H(+) antiporter NhaP {ECO:0000313|EMBL:OCC09224.1};
GN Name=nhaP {ECO:0000313|EMBL:OCC09224.1};
GN ORFNames=A3Q37_04874 {ECO:0000313|EMBL:OCC09224.1};
OS Streptomyces sp. PTY087I2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1819298 {ECO:0000313|EMBL:OCC09224.1, ECO:0000313|Proteomes:UP000093256};
RN [1] {ECO:0000313|EMBL:OCC09224.1, ECO:0000313|Proteomes:UP000093256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PTY087I2 {ECO:0000313|EMBL:OCC09224.1,
RC ECO:0000313|Proteomes:UP000093256};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCC09224.1}.
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DR EMBL; LZRD01000022; OCC09224.1; -; Genomic_DNA.
DR RefSeq; WP_065487713.1; NZ_LZRD01000022.1.
DR AlphaFoldDB; A0A1B9ENG4; -.
DR PATRIC; fig|1819298.4.peg.5046; -.
DR Proteomes; UP000093256; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000093256};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..462
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT REGION 471..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 54466 MW; C88FCA674458E268 CRC64;
MAAVRISSRS GLPSLLLYLG IGIALGQDGI FDVKFDNAEL TQVIGYAALV VILTEGGLGA
KWKEVRPVLP AAAVVSTIGV AISVGITASA AHYLVGLDWR QALIIGAVVS STDAAAVFSV
LRKVPLPPRI TGVLEAESGF NDAPVVIMVV ALSAVGPVEH WYVLVAEIAM ELAIGAAIGI
TVGWLGSLGL RHVALPASGL YPIAVMAIAV SAYATGALAH GSGFLAVYLA AMILGNSKLP
HWPATRGFAD GLGWLAQIGM FVLLGLLVTP HDLVDDFWPA VVVGLVLTMV ARPVSVFLSL
APFRIPGREK ILMSWAGLRG AVPIILATIP MVSGVEGSTR IFNIVFVLVI VYTLIQGPTL
PWVANRLNIA EDPAEADDLG IESAPLERLR GHLLSVAVPA KSKMHGVEVG ELRLPAGAAV
TLVVRENQSF VPSPATVLRR GDELLVVATD PVRDRAEERL RAVAEGGKLA GWLGTGSPAS
GAPGATGPQG GSAIPQAMKL AKKLGGAGAD TRTGVNGSGG AGSGTKTRP
//
