ID A0A1B9EUL0_9ACTN Unreviewed; 412 AA.
AC A0A1B9EUL0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Precorrin-6Y C(5,15)-methyltransferase {ECO:0000313|EMBL:OCC11347.1};
DE EC=2.1.1.132 {ECO:0000313|EMBL:OCC11347.1};
GN Name=cobL_1 {ECO:0000313|EMBL:OCC11347.1};
GN ORFNames=A3Q37_03039 {ECO:0000313|EMBL:OCC11347.1};
OS Streptomyces sp. PTY087I2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1819298 {ECO:0000313|EMBL:OCC11347.1, ECO:0000313|Proteomes:UP000093256};
RN [1] {ECO:0000313|EMBL:OCC11347.1, ECO:0000313|Proteomes:UP000093256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PTY087I2 {ECO:0000313|EMBL:OCC11347.1,
RC ECO:0000313|Proteomes:UP000093256};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCC11347.1}.
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DR EMBL; LZRD01000011; OCC11347.1; -; Genomic_DNA.
DR RefSeq; WP_065484094.1; NZ_LZRD01000011.1.
DR AlphaFoldDB; A0A1B9EUL0; -.
DR PATRIC; fig|1819298.4.peg.3161; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000093256; Unassembled WGS sequence.
DR GO; GO:0046025; F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF06325; PrmA; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OCC11347.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000093256};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OCC11347.1}.
FT DOMAIN 18..182
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 412 AA; 42853 MW; 117CE15845D8FCE6 CRC64;
MADRVTVIGW DGSPLPGAAT AALSAATLVA GAAHHLALPE VPPNAERIRL GSVDLAARRI
AGHRGSAVVL ADGDPGFFGV VRTLRAREHG LEVEVVPAVS SVATAFARAG MPWDDAQIVV
AHPRTLRRAV NVCRAHHKVA VLTSPGAGPA ELALLLDGIH RTFVICEELG TDRERVTVLT
SDKAADHAWR DPNVVIVIGS GPETTAAGAW IAGRLPAYPQ GIRGWALPAQ AYRAAGAERM
QESGEGEFPG LRAAQLARLG PRTGDLLWDI GSGSGALAVE AARFGAAVLA VDADPAACAR
TEAAARAFGV PVQVVRGSAP HVLERLPEPD VVRIGGGGVP VVRAVVDRRP ERIVTHASNR
DEAEALGAAL TGNGYTVACS LLQSVDLDTE VWTERERSVV FLLSAGRSDL AP
//
