ID A0A1B9EWF2_9ACTN Unreviewed; 386 AA.
AC A0A1B9EWF2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=3-methyl-2-oxobutanoate dehydrogenase subunit alpha {ECO:0000313|EMBL:OCC11813.1};
DE EC=1.2.4.4 {ECO:0000313|EMBL:OCC11813.1};
GN Name=bkdA_2 {ECO:0000313|EMBL:OCC11813.1};
GN ORFNames=A3Q37_02505 {ECO:0000313|EMBL:OCC11813.1};
OS Streptomyces sp. PTY087I2.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1819298 {ECO:0000313|EMBL:OCC11813.1, ECO:0000313|Proteomes:UP000093256};
RN [1] {ECO:0000313|EMBL:OCC11813.1, ECO:0000313|Proteomes:UP000093256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PTY087I2 {ECO:0000313|EMBL:OCC11813.1,
RC ECO:0000313|Proteomes:UP000093256};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCC11813.1}.
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DR EMBL; LZRD01000009; OCC11813.1; -; Genomic_DNA.
DR RefSeq; WP_065482424.1; NZ_LZRD01000009.1.
DR AlphaFoldDB; A0A1B9EWF2; -.
DR PATRIC; fig|1819298.4.peg.2610; -.
DR Proteomes; UP000093256; Unassembled WGS sequence.
DR GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:OCC11813.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000093256}.
FT DOMAIN 62..343
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 42520 MW; 8FBA55D37D01D9B6 CRC64;
MTVESTAAAR KPRRASKRTS AAKKPQSADP QLVQLLTPEG ERVEHPDYSI DLSAEELRGL
YRDMVLTRRF DAEATALQRQ GELGLWASLL GQEAAQIGSG RALRDDDYVF PTYREHGVAW
CRGVDPTNLL GMFRGVNHGG WDPNSNNFHL YTIVIGSQTL HATGYAMGVA KDGADSAVIA
YFGDGASSQG DVAESFTFSA VYNAPVVFFC QNNQWAISEP TERQTRVPLY QRAQGFGFPG
VRVDGNDVLA CLAVTRSALE RARRGEGPTL VEAFTYRMGA HTTSDDPTKY RADEERAAWE
AKDPILRLRT YLEKSGHADE AFFTALDEES ETLGKRVREA VRAMPDPEPM ALFEHAYADG
NSLVDEERAQ FAAYQASFAD SAEEGK
//
