ID A0A1B9G622_9TREE Unreviewed; 1092 AA.
AC A0A1B9G622;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=ATP-dependent RNA helicase DOB1 {ECO:0000313|EMBL:OCF26448.1};
GN ORFNames=I302_04133 {ECO:0000313|EMBL:OCF26448.1};
OS Kwoniella bestiolae CBS 10118.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296100 {ECO:0000313|EMBL:OCF26448.1, ECO:0000313|Proteomes:UP000092730};
RN [1] {ECO:0000313|EMBL:OCF26448.1, ECO:0000313|Proteomes:UP000092730}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10118 {ECO:0000313|EMBL:OCF26448.1,
RC ECO:0000313|Proteomes:UP000092730};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus bestiolae CBS10118.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092730}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10118 {ECO:0000313|Proteomes:UP000092730};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; KI894020; OCF26448.1; -; Genomic_DNA.
DR RefSeq; XP_019047518.1; XM_019190770.1.
DR AlphaFoldDB; A0A1B9G622; -.
DR STRING; 1296100.A0A1B9G622; -.
DR GeneID; 30208532; -.
DR VEuPathDB; FungiDB:I302_04133; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000092730; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OCF26448.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000092730}.
FT DOMAIN 178..334
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 414..618
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..61
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1092 AA; 122199 MW; 72DBDFC54F80478E CRC64;
MAPKDPSSSA GPSTPREKKH RKRNVKERSA ETSDRPVKSA RIDEIDDVQE EEVEEDETAQ
AGGDAMDMLD SGVGSSSKTG DPMEVLEGQT ENGQDVEGAT VVKADEFETE AEREVEASKG
LDGAAAGEEG KMKLVHQVRH QVAVPPNYPY IPISQHKRND PPAREYKFTL DPFQFVATSC
IERNESVLVS AHTSAGKTVV AEFAIATCLK EGRRVVYTSP IKALSNQKYR EFLETFGDVG
LMTGDVTINP TASCLVMTTE ILRSMLYRGS EVMREVAWVV FDEVHYMRDK ERGVVWEETI
ILLPHTVRYV FLSATIPNSM EFAEWITSTH EQPCHVVYTD FRPTPLQHYL FPAGSEGIYL
VVDERSNFRE DNFQKAMAAL AAGQGEDSAD PNSGKGRKGN KTRKGGAMKG EKSDIYKIVT
LIMRRNLNPV IIFAFSKREC EDLAMQMQKF DFNTPDEAST VQQVFENAIS GLSEDDKKLS
QIEGILPLLK RGIGIHHGGL LPILKEVIEI LFQEGLIKAL FATETFSIGL NMPAKTVVFT
SVRKFDGKDF RNLSGGEYIQ MSGRAGRRGL DARGIVIMMC DEKIEPDAAK GMVKGQADRL
DSAFHLGYNM IINLMRVEGV SPEYMLERCF FQFQNSMSVP VLEKQLKEAE ETRDAIIVEK
DDEISEYYDL RQQLKEKGQD FQAVISHPSY SLKFLQAGRL VEIKDGDKDF GWCVVVAYNK
VVNPKGRTPI FTESDPPQKQ YIVDVLTKVA SGTSSGNPKD RSSSTLIPPT GTDQGEVAII
ACSLTTVQAI SQYRINLPKD LRGQSEKNTA FKAVGEIKKR MKDGPPLLDP IKSMGIEDKS
FKELVKKIAI LEQRLSSLSI TTSRDLPRLY DLYDKKQESI NAVKQLKRKI NSVHDILQLE
ELKSRKRVLR RLGFTTSDDV VEMKGRVACE ISTGDELMLT EMMFGGTFND LSPEQCAAVL
SCFVFQEKSE AKVRLKEELA SPLRVLQETA RRIAKISNES GIPIVEEEYI QSFKVEMMDA
VLQWCKGAKF SDICNLTDIF EGSIIRCFRR LQELIRQMGQ AAHAIGNTEL EEKFGKSMEL
LERPNTVVFN PS
//
