ID A0A1B9GIL1_9TREE Unreviewed; 683 AA.
AC A0A1B9GIL1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Coronin {ECO:0000256|RuleBase:RU280818};
GN ORFNames=I316_07524 {ECO:0000313|EMBL:OCF30801.1};
OS Kwoniella heveanensis BCC8398.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF30801.1, ECO:0000313|Proteomes:UP000092666};
RN [1] {ECO:0000313|EMBL:OCF30801.1, ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|EMBL:OCF30801.1,
RC ECO:0000313|Proteomes:UP000092666};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP
CC route): step 2/2. {ECO:0000256|ARBA:ARBA00005142}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the WD repeat coronin family.
CC {ECO:0000256|RuleBase:RU280818}.
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DR EMBL; KV700141; OCF30801.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B9GIL1; -.
DR STRING; 1296120.A0A1B9GIL1; -.
DR UniPathway; UPA00610; UER00666.
DR Proteomes; UP000092666; Unassembled WGS sequence.
DR GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006226; P:dUMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR008181; dUTPase.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR NCBIfam; TIGR00576; dut; 1.
DR PANTHER; PTHR10856; CORONIN; 1.
DR PANTHER; PTHR10856:SF0; CORONIN-LIKE PROTEIN; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF00400; WD40; 3.
DR Pfam; PF16300; WD40_4; 1.
DR SMART; SM01166; DUF1899; 1.
DR SMART; SM01167; DUF1900; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OCF30801.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000092666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280818};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3..65
FT /note="DUF1899"
FT /evidence="ECO:0000259|SMART:SM01166"
FT REPEAT 84..119
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 142..184
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 187..228
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 408..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..445
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 73126 MW; B734F6CC5F46B4A4 CRC64;
MSRFVRSSKY RHVYGNKSKV SYENAKISGS AWDTDLVTAG GKYLAVNWQV SGGGAFGILP
LFSPTTPPQP TGFPTKLPDI IPLARGHTGP VLDTAWSPFD DQIVASAGED GKVFIWKVED
SLFEGWGEEH WAPQDLSPQA RLSAGGRKVG QVVFHPTSSN LLTAASGDHL VRLWDISTGD
DTPKIILKGH NDSIQSIAWN AIGTQLVTTC RDKKIRLFDP RAGTDAVRIT DGHGGVKGSR
AVWLGDRDRI ATTGFSRMSD RQVSLWETGG LTNLDTQSLD SSAGVIMPFY AEGNDVLFLA
GKGDGNIRYY EYEGDQLHFL NEYKSSEPQR GMTFLPRRAL DVKENEIARA YKLAGGNIEP
LSFIVPRKAE SFQSDIFPPA NSIEPAQTAA DFFAGKTTRP KLVDLETRAT SSNSAPIPSS
TIATPKPSTP APEPTYTPPT ASTPSPAPEL VKEEFKSTPA ASAVPASVRK EIDSVPEVTA
KGLEIEQPDS EDEQPSKVAE PVEVVQENLA NLTVKDNLKS ESNGSVTAPS DTLLIKRLSS
SATIPTRGSP LSAGYDLYSA EEKVVPARGK ALVDLQLSIA VPEGTYGRIA PRSGLASKHS
IDTGAGVIDA DYRGPVMVLL FNLSDNDFTV TKGDRVAQLI LERIVMAPIA EVDDLESTTR
GSGGFGSTGG FGAAVKEVVG KII
//
