ID A0A1B9GLX4_9TREE Unreviewed; 906 AA.
AC A0A1B9GLX4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Multifunctional beta-oxidation protein {ECO:0000313|EMBL:OCF32090.1};
GN ORFNames=I316_06246 {ECO:0000313|EMBL:OCF32090.1};
OS Kwoniella heveanensis BCC8398.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF32090.1, ECO:0000313|Proteomes:UP000092666};
RN [1] {ECO:0000313|EMBL:OCF32090.1, ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|EMBL:OCF32090.1,
RC ECO:0000313|Proteomes:UP000092666};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; KV700130; OCF32090.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B9GLX4; -.
DR STRING; 1296120.A0A1B9GLX4; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000092666; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 2.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000092666}.
FT DOMAIN 778..884
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT REGION 600..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 96981 MW; D705F97FD3358D1F CRC64;
MSQQQPVSSG AQLDFKDLVV LVTGAGSGIG RVYARFFGGR GSRVVINDVS AQAAQAVVDE
INKAGGQAAA APGSVADGQQ VVDAAVKAFG TVHVLINNAG ILRDKAFKNM SDQDWDLVTL
VHLKGSYACT KACWPLFRQQ KFGRVINTAS AAGLYGNMGQ ANYSAAKMGL VGFTRTLARE
GVKYNIKTNV IAPMAASAMT ETVLPPDMLK GLKPEFIAPF VGVLTAKNGP DVNGRIFELG
AGFISEVRWE RSKGAIWRTD DSFTPSAVAA KWSEVQDFDQ PEHPLNSEDG DMMGWAKQSK
SLPPNKQIEP PIDFKNKTVI ITGAGAGLGR DYALMFGKLG ANVVINDVSK AGAEKVVEEV
NAVGGKAVTA VCSAEDGEAI VKAAVDAFGT VHVLVANAGI LRDKAFVNMD EKMWDQVIQV
HLRGTFKCAK AVWPIFQKQK YGRVITTASP NGIYGTVGQA NYSTAKAALI GLARSLAIEG
SRSGILVNCI APRAGTAMTA TVWPKELMEA MKAEYVAPVV GYLASEACED TGTFYEVFGG
YAAQMRWQRT YGVSFPNDRE LKPESIVAKW EEITTFDDRA TNPTSGPEAL QQIMENFSNT
AGAADGEGSN EDPEDTPEIK EAKRQRPEPE EFTFTERDVI LYNLGIGAKV EELKWTYENA
DGFEALPTFG VIPQFGSSSS LGMDFVPNFN PAKLLHGEQY LKIAKPIPTS GTLVNHVQLL
EVLDKGKTAA VTVRVITKEK GSGDTVFENE STVILRGSGG FGGKKNGSDR GAATAANAAP
KRKPDAVVEE KTTLEQAAIY RLSGDYNPLH IDPDFASMGG FPKPILHGLC SMGIAGKHVL
KTFGPYKDIK VRFAGTVIPG ETLVTEMWKE GNKVIFVAKV KERDAPALSN AAVTLVEGDK
PPKAKL
//
