ID A0A1B9GNT4_9TREE Unreviewed; 1376 AA.
AC A0A1B9GNT4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Calcium/proton exchanger {ECO:0000313|EMBL:OCF32769.1};
GN ORFNames=I316_05404 {ECO:0000313|EMBL:OCF32769.1};
OS Kwoniella heveanensis BCC8398.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF32769.1, ECO:0000313|Proteomes:UP000092666};
RN [1] {ECO:0000313|EMBL:OCF32769.1, ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|EMBL:OCF32769.1,
RC ECO:0000313|Proteomes:UP000092666};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV700128; OCF32769.1; -; Genomic_DNA.
DR STRING; 1296120.A0A1B9GNT4; -.
DR Proteomes; UP000092666; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF03733; YccF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000092666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1191..1211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1223..1246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1258..1279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1291..1315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1321..1341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 391..444
FT /note="Inner membrane component"
FT /evidence="ECO:0000259|Pfam:PF03733"
FT DOMAIN 784..899
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 1188..1339
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..331
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1062
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1376 AA; 149031 MW; 2BE81940B53EBDF7 CRC64;
MSTPTQQRPH PIATPQSVSP PSQYQAALSP GRASSIRSFT TATEDDEYYD SAFRPRSAAP
GMASLESTPR GGAQGVGSGR GMPQSAYGSS FGSPNATWSN QGNSNAGSMP RPARVPRFLS
TGVYQPPTAQ TTGSMSRSAS RARPPLNSQN SGGVKQASRA NDDDEVEDRG AELIRQRQKE
RRQARLKKQH LELERRLAAE EGVTPAMTPD PSAPNTGVPD ESFLTQQNRG SMGRSVSRSR
APSSDRRKMP SDGYFARAAS VAGSETPRDG GLSPRDELRA PSIMSSTADE EDVEALAHER
ASILDEIVHD VVEEETGGEM SDEDHSDEDG GGDDEGVTLR DRQDALNIEH PFGLPIWKPA
LYRKSRSVTR NAESALHSIP SAAAERHLLP GNILWVVFFG WWLALVCFFV AVLVSAAEVL
GGGRGGYGKT VRGLAWYIGW PFGKYVEGEG PPEDEHSDNE DDDEERLNNH ERTNYGTWAS
RSESPLSGRG EHARVPSDGA SSGITVRDAQ RRGSLGLHSG LPDEPSARPS ASASSLAGAS
SSTIRGVENG HERHPTVSFA PNTKRQERSQ GSMDERSSLL GKSGTGTSGS GNSGFRRPRN
KRAKVLGRLI YWPGFLLIVA PIMLSICILC WFFVITIPMA KLNWALLKLL WFRPLEINFR
SAPKVSVPLL TPHGSPESAD GSGSTTLRDD GSPSGYTLKR ARLTAGQVAP TSGPTSTVLL
CTYRAIGLQY YKYTVGGVNI LFINLLPLVF FTIIDGMIIL PFVEREEHAG HAIAPFLRFI
TSQALIFVLA LASVIPLSYF IGMAVASISA QSSIGMGAVI NATFGSIIEI ILYAIALTQG
KGRLVEGSII GSILAGVLLM PGMSMCSGAL KRKEQKFNAK SAGVTSTMLI MAIIGTLTPT
MFYQTYGSFE LHCEGCPEPK QDFNTSPVPD MNTALLRAGD VWMCDHCYYE HPDPERDPFY
QNNVKTLMYC CAAILLFSYL IGLWFSLRTH AAQIWQNPQQ LMKSDEAAAV SAMHPAVKST
LTQRITPQAV MQHILPMHKS ATSSPIQPSR SAAGSPKVST MKLPSHPNLR PRIPEEAGEA
RESERMEPGP SNTEGRLTSG TFNLPQGYTP FLEGVDRDMK SNSHLTPMRL PSTLTTEDFT
RAVAVATVSA LRHQGGNQAM PVIRPPGGEE QEEEHGGHEA PSWTRDVSAG VLLGCTLLYA
IIAEILVDVV DVVMQGSGID EKFLGLTLFA LVPNTTEFMN AMSFALNGNI ALSMEIGSAY
ALQVCLLQIP AMVAFSALYQ PDKMGDVVDT FTLIFPRWDV IAIILSIFLL TYTYIEARSN
YHRGSILVLA YVVLIMGFYY APDRSQGDVD SDLIVGPEGL DAAKVFLSTA FTKLWA
//
