ID A0A1B9GQ97_9TREE Unreviewed; 984 AA.
AC A0A1B9GQ97;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=I316_04973 {ECO:0000313|EMBL:OCF33232.1};
OS Kwoniella heveanensis BCC8398.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF33232.1, ECO:0000313|Proteomes:UP000092666};
RN [1] {ECO:0000313|EMBL:OCF33232.1, ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|EMBL:OCF33232.1,
RC ECO:0000313|Proteomes:UP000092666};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; KV700126; OCF33232.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B9GQ97; -.
DR STRING; 1296120.A0A1B9GQ97; -.
DR Proteomes; UP000092666; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000092666};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 530..616
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 106877 MW; E0450194FBEA15CE CRC64;
MAASSTSSSI GPDGNTPVPS PTKAFASYVP HLTSALDSLT THAAALPDKS DLSFHRTLDR
QFAKDLDSAS DRLLKLTERL LSLVDHSQRS AAEKGKSKAK AGPIKGRRRK LEDEDDIVDG
FRQGVVGVVD GLLEDADSCL DDLRGEKKKA AIAVKPALAA AAGQKLPGPF SKPKERLPLS
IFHASDIPKP QLLFHDQVDN FPSSGPWRPS MTEKPHAMVP LDFEAPLDFL LTREEEMDPS
KEAWRREREI RLRSHPYFYE TRNLPYPTSM FIEAPPTPPK SFQDTPFEFV DTPEALEKMV
EQLKKAKEIA VDLEHHQMRS YSGFTCLIQI STRGGDYVVD TLKLRKELRE GRLGDVMSDP
SIIKVFHGAD SDIIWLQHDF EIFVVNLFDT YHASVVLDMK ERSLASLLSL YCNFEADKRY
QMADWRIRPL PEAMLHYARS DTHFLLFIYD NLRNSLLQQS SRPPSPDANG NAIIELGRRN
PQQAMRDVLN RSADTALKMY ERDEYDEETG RGTGGWLQAA RKWLPKDAID EESGWVFKKL
HVWRDRLARQ LDESPFYIMP QDLLKRLALL QGSSPVTIKR EISNKRSRIP VSPIVEKRAD
ELVQIIKEAK EEFAKSGSSK QVVDSSSVQV QDIVPKPSTA PKAVAITPVV QVAAGQSAAV
PDVWGSVSSP VQKTAKPSAK SGLFGSTIKP SAPASSASSL SSSKTAKAST SGLFGSALPN
KAGAQKTVST PVKSKARAMS PGFAAVQQTI HGALEPKPVP QTPGQDVDIV KAIQPEQVPF
VPAASRKTAS ASDPASSSAN KKDTSEGVGS DAGASTAKAA ESTAASTKQS TTLSEDGVVQ
VKKVRKQKKR DRVGSTSTPN DASASGTGLS SGKKLKLSPP AEEPNGATFP AAGVGAGRVK
AKKGKKKIKV EDVPAFDYAN EPNFLDQPSA AAVQGESSGK GKKDKKKKKP QAGIGALEIP
TFGKRPARDM SQPKAGNKSQ TFAS
//
