ID A0A1B9GRK7_9TREE Unreviewed; 3719 AA.
AC A0A1B9GRK7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:OCF33692.1};
GN ORFNames=I316_04766 {ECO:0000313|EMBL:OCF33692.1};
OS Kwoniella heveanensis BCC8398.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF33692.1, ECO:0000313|Proteomes:UP000092666};
RN [1] {ECO:0000313|EMBL:OCF33692.1, ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|EMBL:OCF33692.1,
RC ECO:0000313|Proteomes:UP000092666};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI669504; OCF33692.1; -; Genomic_DNA.
DR STRING; 1296120.A0A1B9GRK7; -.
DR Proteomes; UP000092666; Unassembled WGS sequence.
DR GO; GO:0004672; F:protein kinase activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:UniProt.
DR GO; GO:0019219; P:regulation of nucleobase-containing compound metabolic process; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000092666}.
FT DOMAIN 2556..3107
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3359..3684
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2017..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3141..3189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2017..2032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3146..3160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3719 AA; 419275 MW; D4A254CF9ABBADCB CRC64;
MAAPPPPQPP AAPTGPTAGP SAVNRTGRPR KASTATPHPI PTGGTPAAET PTPSASAVGG
SMAMPPPSFS SNGPMTVSDC EFMAAQLLEQ GVTTRKKLEI AFELRDSAES NRDFGFYEKY
LSIFIPALIT ILGEEKSITF TKDNIEQRFR HTLLAFLQRL PHTEPFRHHM SSVMDLCVKL
LKAENEENAL LCIKIMIDGL RSNKEQMEPY IEPFLDLVKQ MYSNTKAVVE KEFGPTGGAP
AAAAAPKPTV AAGQQTGPAP SPAPATPASD GSAAPQAPPP AQPQQPAPAA PQPSSSQHVI
LPHALHSPKV LTECPIAVVL IFQTYKQIMQ TAMLDFYPLV IDSIKIQPEP QRLAHLEAKE
KGEIFVGVAS GIGNREMYAE LIKAQVKTMA FLAYVLRGNQ GNNKEYVDVF PEACLRLLRD
CPPEDVGTRK ELLVATRHIL TVESRACFIP YIDVLLEERV LVGTGVSSRE LLRPLAYSVV
ADLIHHVRND LPLSQLTRVV YVFSCNLNDS TFNSSIQTMC AKLLNTIIDS IHTKADSNEF
ARIMRGMFFT FLEKLTAMSE AHDRLKAIGL RDKGKGKAKE ETDGDVAMGD PNVDIAEDKL
TNGWRDIEQA MPVHSVAYAN ESLESFCRES RYLFKTLLHT FRTLLTYTRQ TENAPPQPDG
ELLSKFFEHS LKCLAIFDFM GRDPREPKEA IELLSQILLL FEPHVFGEVW SSHMPFFSEL
AINNGQVFPI LQMLITHEAV SHQLVAILLK HLMSNLEGLG SVDKQQAILT LKMFKISFLA
INTYIASNEV VLVPHLQKLI MNSFEYAAKS DDPAIYYQIL RALFRSIGGG RFEALYKEVL
PILQEMLDNL AFLLQHAPDD AQRDLFVELT LTVPVRLTNL LPHLSYLMKP LVHALGAGPD
LVSQGLRTLE LCIDNLTAEF LDPTMGPVLR SLMAALHKLL KPIPSNRNHA NAALKILGKL
GGRNRRFQEV DTVLDYKLFS DRLESPISFD GSRHQLQLGP LISTASTVLS TEGQVLRDDG
LQVLMYSAMT IFQEGAPNPE NNATFQGVMT SLFLACGRPN IGEKALDFVR NLCRRAFAIE
LGRTEGTDPN SKPFPDHARK RFLPLTNALS DCFVATLHDS TPAERPALSD LLSTIVTDFK
ELALSPTFAG KVDGSRSFER MVAFLAHRLV SLCHEEDWSK KMAGVTAMSA FVHKIELSRK
MIIDFELDFV RALLFCLRDA PKDTPKTSDE VIDLIKYLLR TCQSQDDGKP RLPRLSEALV
SELNSQSPVA RRAAKECIDT LAEVTQQSIE DIVTNIAKAK LLNHEHGPIY SKPLRALPFA
MQVGNISAVT YLMDLRPCVP ETSEEFVRLL HEVLALADVD DANLINKPAT HKQENWLKTL
RISCLKLLRA SMGAPEFLNK PHLNQLRARI IQVYFKHVYS TNPDIVEIAH DGLRDVLHQQ
SKLPKDVLQQ GLRPILVNLA DAKRLSVSGL DGLARFLELL TNYFKVEIGV KLLDHFKTLG
DHQMLLKAAY SPLDDNPDIS RMARLVNIFR LLPSNAVQYL DDLVSNVVEV EALLHQSVPG
PFTDNLGRYL NRYSKDGAKN LFDNIRNPRY VWTYRNIIAS GSAPAFYEEL STRAEALCQL
CFKNPEAVEF VLPGLYLIRE LSRISPTWLS DAEPALEPLV NVWRTIVSKS RDPKSDMTSY
HYQQMPSLLL EMFMTSLKHQ QHIPLLSHVV EAYEVRASFE RSHVSFFLYQ QVALQESLEY
RKEVIEYFFN LYEDETVPWA FKTNALRVII NPTLRVHFSQ PGAEQSIISP QLVAKITTLM
WRPLATTSAA RQREDTHLIE VFALTTLLVQ HCSAKVNEAR KEIFKLAWMG INLLEPTVKL
MAYVLAARFM ATYETPVKFV RLTWTGVLRL KDTDNRVLYR QAIDTLASSL SVRDPPSNGT
PEWAKLLRTV LIEEGHATNQ LVTVCELLVN HPDLFYDYRE LYVPHVANSL SKLAFVQAAT
PELKKLTVDI VELIFNWEKR RMAARDAEMM DIDEAHKRPA DHSADPSPIK KQRLDRAGTA
ISGSSGGGWA APGQVRELMT AHLLRLVSTS PESVTRNGLT RRALDLFKEI LGPKGLPNVH
VKLGFFQRTM TSEINDNTRT TVANSTEVIA AAAAVRDSHW VRVNLGLLSK LLEKVWVSDE
TELHEVVSPL TEDLFAEMPA DENAEAEPEA KGLLAFVQNA VNDGLNSSLR SSSHLPGTLF
LLKVWLKTHP KILQSEAISS ALLKVLGNLV KVHTANTNPP GPANDPDSTA KLIMSVLDIL
RHRVADLREQ RKHLYSITTT LVERSLSPAL CRYVLRLIRQ WVIEDNEGAA HGKEKAAILL
KMSIFEQRDD ELFQEYLDVI FEIYEQDSLR GTDITHRLEP AFLLGTKSKN ALQRTKFLDK
LEQSLPRSLD GRLQYLYSLQ NWDTLADSYW IPQILSQLLG IVDHEESLIR RPVTTALQSD
PILTLLKDAT VGDIVSPARN LIHLDNDLAH RLWVAIFPMC WASLSRSQQT AFTPYIVKLL
SKEYLRKQVE MRPNVVQTFL DGILPCKPAI TLPPLLVKYL AKTYNAWYVG FEILTKLSDI
YRGDEGLRDS CASALSELYA ELCEEDMFYG LARSRCVFPE TASALTYEQN GLWPKAIELY
EQAQIKARNN LLPFTEDEYC FWEDHWILSA QKLQNWENLT ELARIDSDAD LLLECAWRLS
DWTSPDRDMI DQNIARISDI PTPRRKTFEA FVALLRSHLA REPPNEFFRV LDEAQQVTLR
KWVSLPTNIT AAHLPLLQMF QQCVELTEAA QVFDSLQMTN QSNLEMRCNS DLKTIFTTWR
DRLPNFWDDI SVWSDLLAWR QHVFQAVTRV YHPLIPQGDT ATYGYRGFHE TAWMINRFGE
VARRHGLLDV CSVALNKIYM LPNIEISEAF LKLREQALCF FQKPDKFNDG LENISTTNLM
YFAPPQKAEF LTLKGMFISR LGQNEEANAE FAHAIQMDMN LPKAWAEWGR FNDKLYRERP
ENVPAILASS AVSCYLQAAG LYNNHKSRGL LLRVLWLLGL DDTRNTISKA FENYKGDLVI
WYWITLIPQL LMSLSHREAK QARLLLLRIA KQYPQALFFH LRVSREDFVS IKKQQMQSRA
AAARRAEAQA KAAAANAAAA AESAGEVKSE ENKDAKEEPN ATAPDGQATQ SVPNGAMAPP
ATAPPRQPWD HVDEIMNMLK TAFPLLALTM EKMVDQISIR AKPNSDEDIY RFFSALLADA
MQQWGGRNGM PNDDGELSAQ TKDNLAKFAT NLNGDLKAMI EKDFMKDMPK LREYIKRLQR
WRDFYEKNLD ARPKIQPLDQ GGCNLTEFHH AKFDDVEIPG QYVHHVDQGE EFVKIARFAP
KAELGRGHGH CFRRITMIGS NGSSYTFHVQ MPAARHCRRE ERLTQLFRIM NSVLKKRKES
RRRNLQFHLP TATPLAPQLR LVQADSSYVS LQDIYEDFVA SKGMSREDTT LAYFDRIKQL
HDPAIPRNDH RFIQLKAEVM EEVQTKMVPE NIMTNYMIKT MGNAESLWLM RKQFALQTAT
TMFLTYLCCL SNRTPSRFYI SRKSGLMYMT EILPAFAPGQ PLIASSEVVP FRLTPNMQNF
ITRVGIEGVV TAATTAIARS LTQPEFDLSG TLCLFIRDEL LIWHNTYMKD SRMEAPLINH
VYKNVDNFIR RAGTMGYIGE NKEKSPNAPP TVHAIVTLIS QATALTSLAQ MNDTYMAWF
//
