ID A0A1B9GV51_9TREE Unreviewed; 772 AA.
AC A0A1B9GV51;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=I316_03467 {ECO:0000313|EMBL:OCF34920.1};
OS Kwoniella heveanensis BCC8398.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF34920.1, ECO:0000313|Proteomes:UP000092666};
RN [1] {ECO:0000313|EMBL:OCF34920.1, ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|EMBL:OCF34920.1,
RC ECO:0000313|Proteomes:UP000092666};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; KV700123; OCF34920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B9GV51; -.
DR STRING; 1296120.A0A1B9GV51; -.
DR Proteomes; UP000092666; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF02020; W2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000313|EMBL:OCF34920.1};
KW Protein biosynthesis {ECO:0000313|EMBL:OCF34920.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000092666}.
FT DOMAIN 579..753
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 469..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..772
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 86008 MW; 18B9CFA933545E58 CRC64;
MPPKKGQAPR DQPKAKADNV NEAPLQAVVL ADSYNRRFEV LCQDQPRVLL PLCSTPLLAW
TLESLSLSKV RQVFVFCGVH ADKIRAFIES SPYRHTLDIQ CLSSQTAMSA GDALRELDDM
HVLNPENPFV LVHSPIVSNY DLSKMIEVHK QRREVDKNFI MTMEKINTET IHRYRRHPES
PIMLVHPPSS RLLHYAPHPL SPSQPRAAFP SSLFLDPFPT SIDTYEIWSG TPSSSSSNRG
GYRDLGVDIC EADVPALCTE NFDYHDMRRH FVNGVLTSEL LGKKIAVHVV GKDDPEIEEG
KGDVRSGAGG NYIERVRDTR TFGEISRDVL RRWAFPLAPD MNEPGGVQYE LRTGNVYVAR
DNVVLSRTTT LNGPLLIGPR SALAHNTHIH QSTLGADCSI GPNTTVTQSY VFDDVRIGAN
CTLRECVIGE GVVLHDDVKI GRGALLGNGV SLGRGTVVPE FARIGKERYR GDGYDTDEDE
EEDEDEKDRR LQVLGPDSIG YLWPNEEEEP PSDSEDEADD PYEHPRNKKL LQLGRRLSNL
SSTDVSLSTL SKASSEASSP ESIASSASLP DMPTLSLDSG PPAAFFDEAR DSLRRAYEED
HKNENAIIEF RTLVLSYNAG LDRAREEIVK FFLSKIDANS GAAGVLKSTT AIFTRWGPLA
HGFTSDLTNI VLDAQAFCVN NSEYTPWFGI ILRGLYESDT LGEEELIEWR SLSAARGEGT
KDEEEKKKWV EVFGKGKAYV DVLEQMESDD DDDDEDDDDE DEDDEEEESD DE
//
