ID   A0A1B9GX78_9TREE        Unreviewed;      1085 AA.
AC   A0A1B9GX78;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   13-SEP-2023, entry version 22.
DE   SubName: Full=Importin beta-4 subunit {ECO:0000313|EMBL:OCF35620.1};
GN   ORFNames=I316_02675 {ECO:0000313|EMBL:OCF35620.1};
OS   Kwoniella heveanensis BCC8398.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Kwoniella.
OX   NCBI_TaxID=1296120 {ECO:0000313|EMBL:OCF35620.1, ECO:0000313|Proteomes:UP000092666};
RN   [1] {ECO:0000313|EMBL:OCF35620.1, ECO:0000313|Proteomes:UP000092666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCC8398 {ECO:0000313|EMBL:OCF35620.1,
RC   ECO:0000313|Proteomes:UP000092666};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA   Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA   Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Cryptococcus heveanensis BCC8398.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCC8398 {ECO:0000313|Proteomes:UP000092666};
RA   Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA   Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT   "Evolution of pathogenesis and genome organization in the Tremellales.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; KI669498; OCF35620.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1B9GX78; -.
DR   STRING; 1296120.A0A1B9GX78; -.
DR   Proteomes; UP000092666; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000092666};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          27..98
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          517..555
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   1085 AA;  118347 MW;  0EAC3FBA60ACB2E3 CRC64;
     MDANYVSQLR QLLEATIAPD TNIIKAATTQ LNTQFYKNPT CIPALYEVAC TSENQAIRQL
     AAVELRKRIS SGDGRMWKKN PQQLREQIKD SLLQRLTQEE SAIVRHALAR AVAAIADIEL
     TVNPPQWPTL LPGLYQAAAS PTRSHRETAI YVLYSILDTV AESFEAHLQT LFKVFSVSLV
     DPESPEVRVT TLRALAKVAE YIEAGDKHDV KAFQELIVPM LKVLEQAIKD EDDEGVKHGY
     DAFETLLIIE APLVSKHVAE LVQFFLGVAG NKEVDDEMRC GALNVLSWVV RYKKSKVQAL
     GLARPIIEGL LPIGCEDDPE DVDEDSPSRL AFRTLDNLSQ ALPPQQVFPV LTQQLQVYMS
     SGDARMRKSA LMAFGVSVEG CSEYIRPHVD QLWPVIEGGL QDSEVIVRKA ACIALGCLCE
     WLAEECATRH SVIVPILFNL IVDPSTQKNA CTCLDSYLEI LGDDIVNYLT LLMERLLVLL
     ESGTVAVKIT VTGAIGSAAH AAKEKFVPYF DQTIKRLVPF LELQGTDEQS DLRGVATDTI
     GTIADAVGAD VFRPYFQGLM KAAFEALTMD NSRLRESSFI FFGVMAQVFE GEFAQYLPQC
     VPALVASCQQ SEASDEFLDD GEGGSSNPSA LAEAFTTGVS AKDVGEDLGD DEEEDETDLA
     ALEQMFSKVN SAVAIEKEVA ADTIGELFSA TKSAFMPFVE ETVKVLVELL DHYYEGIRKS
     AVGALFAFVK TMYELSEPAE WQPGAQIRVP LHEHVKKIVE MVIPPVFETW KTEDDKSVVI
     LMCAELADTM NKCGPAIVEG RLDEVATFAI EILEKKSLCQ QDPDGDDEAV GVDADSSEYE
     SALISNAADV FGAMASVLGP DFAQAFGKVL PLIAAYTEPK RSQSERSMAI GSLGEIIVGL
     KGGVTSFTQP LFQIISRGLA DSEADVRSNA AFAAGVLIEN SETDLSSQYG ALLGALQPFF
     TPAEHAAPAE FNARDNAAGA VARMVSKNSA ALPLEQVISV LVNVLPLRFD PLENRAVYAA
     LFSVFRTQPQ VLMPHIDHLL QAFAYVLLDP SHEDDTTDET KAELRALVEH LKSQVPDKVA
     AAGFA
//