ID A0A1B9I3S8_9TREE Unreviewed; 1188 AA.
AC A0A1B9I3S8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=I206_03501 {ECO:0000313|EMBL:OCF50182.1};
OS Kwoniella pini CBS 10737.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296096 {ECO:0000313|EMBL:OCF50182.1, ECO:0000313|Proteomes:UP000094020};
RN [1] {ECO:0000313|EMBL:OCF50182.1, ECO:0000313|Proteomes:UP000094020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10737 {ECO:0000313|EMBL:OCF50182.1,
RC ECO:0000313|Proteomes:UP000094020};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus pinus CBS10737.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000094020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10737 {ECO:0000313|Proteomes:UP000094020};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; KI894010; OCF50182.1; -; Genomic_DNA.
DR RefSeq; XP_019011401.1; XM_019155247.1.
DR AlphaFoldDB; A0A1B9I3S8; -.
DR STRING; 1296096.A0A1B9I3S8; -.
DR GeneID; 30171870; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000094020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000094020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 424..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 517..538
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 691..714
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 726..744
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 765..786
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 806..823
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 861..882
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 888..907
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 928..947
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 953..977
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 1130..1188
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1188 AA; 129831 MW; 689BAA170672C6E5 CRC64;
MSQSREEEEQ RMSTSASTTH STHTIKPPRP PSIASLRHNR FYGSSSSSSA GAGPSSRSSH
SHSRRQSLDI AETQPPSPIT YFPNPSTFQS NSASYPQPPI SSTSNSISTS PKNSTFSMSN
SVVSLPEESE FEGPTPKMSL VNLDSAASSP RMTRGGGNSQ LEQRRRSSVA PSTSQGMRQF
STPVNGYGST HTSNSNLGLG LGRTPSLSTL NNPNQDATLS SPRRISTSRV PPGPSTNRFT
VTPPQGLLNL PTHEAYYSAS QPGTATTSRF RDKDLHQSHP LPHSAIPYSN QLATQMTSNS
NSHRRHLSVN SIIHSPLFPG RHSLPHSPTG SVMRKIKRTA STIGMGFGRP DHYDDDASRG
KGGEDEMLED DEGERANGTR VWYSSYVTID WIHDAIKDSS RVRRLRHAAH RSIRGKLANS
WDRIQGWLVV TIVGVLSAVI AFFIIRTEMA LFDLKEGFCG SSWGTAKRFC CAPHHPSGRG
DAGDEENCGD WVEWGEFFAP HQRGGPEGQW IWGGPEFIAY AVVALCLATL ASFLTVYLTS
AAHHTTSKDS TFLTTPTEHN DNKSKQPKQI PTMNNGENSN ERQPLLEGIA NEPITPITEA
FPPTEPPRKI MYYAAGSGIP EIKTILSGFV IHGYLGGWTL ITKSVGLALS VASGLSLGKE
GPLVHISSCV GNIVSRLFLK FECNEAKRRE ILSAACAAGV AVAFGAPVGG VLFSLEEVSY
YFPPKVMWRS FWCAAVAAIT LKSLNPFGNG SLVLFNVTYT KEYHYWEYVI FVFLGVFGGL
YGAIFARLNI IWSRQVRGGT WLKKHPIFEV ALVTILTTVI SFLNPYTRMG GTELVASLFE
ECQPSSSSSF CVNHPHEIAP VIWTIGTALL IKGALTIITF GIKLPAGIFI PSLVVGACFG
RIVGLTMEYI EYSYPTLGIF DVCKETDCIV PGLYAMVGAA ATLAGVTRTT VSLAVIMFEL
TSTLNYVVPV MLGVLIAKTV ADGLEKKGIY DLVIDLNQLP YLDQKHEYLW GSRRASSVAD
KSVPILRADK QHTVRSLTGK LLESVRLGMT DTGFPILVKE RSCLRVIGFL GMNELEHALS
ELSDEPDATL NLMPDDATSH RRRSSAMSIF SFADSYADGQ WSPYDLSRYI DRAPITVQIH
SPLELVQQLF VKLGARQIIV TNSRGVFQGM VTKKNWLNFL GELEEDGH
//
