ID A0A1B9I9B6_9TREE Unreviewed; 2152 AA.
AC A0A1B9I9B6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE RecName: Full=separase {ECO:0000256|ARBA:ARBA00012489};
DE EC=3.4.22.49 {ECO:0000256|ARBA:ARBA00012489};
GN ORFNames=I206_01368 {ECO:0000313|EMBL:OCF52083.1};
OS Kwoniella pini CBS 10737.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296096 {ECO:0000313|EMBL:OCF52083.1, ECO:0000313|Proteomes:UP000094020};
RN [1] {ECO:0000313|EMBL:OCF52083.1, ECO:0000313|Proteomes:UP000094020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10737 {ECO:0000313|EMBL:OCF52083.1,
RC ECO:0000313|Proteomes:UP000094020};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus pinus CBS10737.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000094020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10737 {ECO:0000313|Proteomes:UP000094020};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=All bonds known to be hydrolyzed by this endopeptidase have
CC arginine in P1 and an acidic residue in P4. P6 is often occupied by
CC an acidic residue or by a hydroxy-amino-acid residue, the
CC phosphorylation of which enhances cleavage.; EC=3.4.22.49;
CC Evidence={ECO:0000256|ARBA:ARBA00000451};
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DR EMBL; KI894008; OCF52083.1; -; Genomic_DNA.
DR RefSeq; XP_019013302.1; XM_019153141.1.
DR STRING; 1296096.A0A1B9I9B6; -.
DR GeneID; 30169737; -.
DR OrthoDB; 5479815at2759; -.
DR Proteomes; UP000094020; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0098813; P:nuclear chromosome segregation; IEA:UniProt.
DR GO; GO:0000280; P:nuclear division; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005314; Peptidase_C50.
DR InterPro; IPR030397; SEPARIN_core_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12792; EXTRA SPINDLE POLES 1-RELATED; 1.
DR PANTHER; PTHR12792:SF0; SEPARIN; 1.
DR Pfam; PF03568; Peptidase_C50; 1.
DR PROSITE; PS51700; SEPARIN; 1.
PE 4: Predicted;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000094020}.
FT DOMAIN 1958..2056
FT /note="Peptidase C50"
FT /evidence="ECO:0000259|PROSITE:PS51700"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2152 AA; 237464 MW; 7A20FB914E638364 CRC64;
MPPKATTATK AVPPAPRKVR TTKTTTITAT KDCADELVEG LGKLKIQPIP KRTIVKDSSS
TLTTASSSKL PSTKRPVTSA SAKKIPAPSS STSGSKGKFK VTTVEDTLPW AKSECPEGEM
KPLDRVRGAM QAINNASKDL STAVSSGFKY TTSSQTPTPI TNGKGKEKDT NQSETNEWTN
EKVGKILDVC KIAFRVLRGL DEQGHLQNKG LDVERSSIGI VAKCISMGMF QIAMEMLVGS
RPALLRLYDP RPNPILPKMN GTATPSSASA SSLKSAAPRS HPSSYKSTSR VTAAVEGAPK
EWLEMGRLPS SKDGGELSET LRSLLFSVMM ATWICLLVLV KNKEKLLSTL AIPSNTSEED
LLHPLILASS IPIPQTTFYL HNFYRQVTNI ATLPSTSYYL QLRHLSLLSM SITITPSSDS
RTTPTQFWDT THRTILQIVK EDDGKEKLRE AAQTIDHIVG WVENLAKRRG EKFWFEGKGW
LGLVEMWIGL GRRLGESEII DRPLALLATP TSISSPPSTA GPTPVSRSSA KSSKIRNPEA
EIARVCGDLA KASLQFEKAS SPIDHSLNVG DLITLAYSIT SLTVDGEFVD IAGKAIRAFE
RVRRGCLKDY KVANDSGSAG MEDVKEWLKG SIEFIEILIN PLILDASLTR ELLMSLTDTL
IQYFKPSQYS SSYHYLQRAR VLIDQTADIT QAKDRADWLR CLSTIAYNGA GQSYRSNRTE
EALSLTEISC TWGAETLRLM DGNQQEDKLF TGLREGMSKR WELLSGCHQR LGQKEEMFTA
YSHVFASQSP QILSQIAESS RSKSVAEALA PHAELDNSLK RLVSLILYEP SLYLTHGRRL
IHLMQEEAVP LGSIGAIAER LMGLLEEGEW KDDIVKVNLE IGDAVLELYG EEYPIRRIRV
LSKMLRTILT SGQSMDRFDG LVEEANRLSI QGDHGQDVKL CSYKAEYVSY SLILRAMQSY
HTSPHPSLDV LQATKEVVEK LRQIIIPPTS NNVVSTPEKG APTRKTPLGS LSTLLGLLGH
SLQQIEVLKL LRAFQRNKED LVDGKSTQLA TEYQKLGKTS RAGFVFTQAQ RVIEQSKVLV
SAKVRVESGL RFAAFLALKG DVSKAQEIYT AASVLESEIE ENKTGPYVAR VTDRCDHLER
AAWARRAAAA IYVAQDDSTG AIMQLSASFR LLSRAADAIC RIAASVPGPS TPADKAITED
DPFGAPLPPS AKPKVDGADE PSKDSKIAKT QLNQSTFNGK HLSAYQWNIA CSLLNTILDL
SNAFAYRGTV KECEYFLNLA LGMAETVKSD VLQARIQSKQ AELCFRMRKF EEMGEKLENA
NTALHAIEGP DMVDLHVLKG DLYSRTEMLE EAEQVFQSTS RDIEGLDRVF VANEAVLPTV
RASLTNSKLG KGSEPLLPTA LAHILRQYAW LLKEAGSKEE CEELLAQIKN LPSSTETTAE
QLLLEGRIAL HEAFNTFKTD LFMSSLTESA VAMPMGAPAK RVADRQSTRQ SIQTVLTRAE
EAFLSALSLV SGSGKIEGLR QACLALALLR TFQTSLGNGS EEITASAAGM LASSSAITLQ
RELLEAIESK FVDIVNDDLT WPSLLTAPAT PPESASMDVD DIERSIEVVT EDLDDHNGKL
RAYWEKIKLK YSSNLIQTPD LKDLNILPPD WAVISINVTD DRNTMFISRH QRDHQPIVFC
LPLDRQGRRE GEDDESLFTF DSATTELQDI INSSNDSART AKSVVTREDK LAWWEGRFKL
DAKMKELCES IEFVWLGAFK TIFSPRLPDP TSSIADLKQR LTKIFDSALA ATSGGASKPR
SRASSVPTLP KVDLNDSLLA CFVNLSSKCK DEEIEDLVYF ILDVYQFHGI PVALSELDID
QISIDVKAAL EKVESKIAFS GLTPSKDEHL FLALDKNIQP FPWESIPILR GRPISRIPSL
SFLLDQVKMS NHLRPSLSQS TANPDRNGEI DVRRTVNSRK TFYILNPSGD LDRTEQHFKP
YIDDMVKKAG WKGIIGRPPT ELEMAAALKD YDLVLYFGHG GAEQYIRSHK IRHLPQCAST
MLWGCSSGHL REQGDLDRTG TAWHYMVGGC PSLTANLWDV TDKDIDRLSS HVLKLLHLDS
AHLPDSKSRT NTLLPLSNLS IVQAVNESRE ECKLKYLTGA APVVYGLPVW LH
//