ID A0A1B9IRR7_9TREE Unreviewed; 1939 AA.
AC A0A1B9IRR7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Actin cytoskeleton-regulatory complex protein PAN1 {ECO:0000256|ARBA:ARBA00015110};
DE AltName: Full=Actin cytoskeleton-regulatory complex protein pan1 {ECO:0000256|ARBA:ARBA00020728};
GN ORFNames=L486_04263 {ECO:0000313|EMBL:OCF58233.1};
OS Kwoniella mangroviensis CBS 10435.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1331196 {ECO:0000313|EMBL:OCF58233.1, ECO:0000313|Proteomes:UP000092583};
RN [1] {ECO:0000313|EMBL:OCF58233.1, ECO:0000313|Proteomes:UP000092583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10435 {ECO:0000313|EMBL:OCF58233.1,
RC ECO:0000313|Proteomes:UP000092583};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Kwoniella mangroviensis CBS10435.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10435 {ECO:0000313|Proteomes:UP000092583};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KI669462; OCF58233.1; -; Genomic_DNA.
DR STRING; 1331196.A0A1B9IRR7; -.
DR Proteomes; UP000092583; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00052; EH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02205; WH2; 1.
DR PRINTS; PR00499; P67PHOX.
DR SMART; SM00027; EH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000092583};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 227..262
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 228..317
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 264..296
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1004..1021
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1198..1257
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1613..1802
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1840..1929
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1550..1594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..601
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..752
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..840
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..911
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1939 AA; 211884 MW; A14A95C6DBFCDFCC CRC64;
MQPNQWQQQQ FSYPSFQQPQ PTGAPQGQGG FGGNNVNPSF LSTQPTGYPG QQQQLQPMQT
GYQPQQPQRT GMMGGISQGN TGNNYSFLNQ PPRSTNNLTP QMTGYPGGGA SGLMSQQTGY
QPSGLMSQPT GASGLLSRST GLMSQPTGMG MGMGRLQPQA TGLPHDPRLQ QMMQSFMPSN
ISQPFAPSGL PQFNQPQSQQ PLTQSFQSLL QNPSVNTPKV PWTLSRQEKK DYDQIFRAWD
TKGDGFISGE MAREVFGQSG LDQDNLMKIW NLSDKDNRGK LNLPEFHVAM GLIYRALNGN
TIPDVLPEEL VPASMRDIDT TVNFMKDLLK HEASSRSNAS SPGYGGNSPA PTGASKDALM
YKHSDERPST YKPSSRHLDR KSVRYAGEDP DAELKDIRRK LENTSTFLEK SAEKSIEDEE
LEEETEALHY RVKRIQEDIE YTSKGRRTVE KDEERRKLER ELLYLMHEKL PELERKQERR
LEEKAMEERA GVRRRDERNQ THGRYDNRDR DRNRDDHDRY RGTFDRDRSR ERDRYDDRDR
YDRDRRGSRD RDYDRYDRDR RGSYERPRSP PSTRSPPPAP PPASVAAAAS APPPPPAPAQ
AAAPSTKNMT PEERKAYIRE QAQKRINDRL RALGVESAPA EETVDTSVQD RLEKEKKEAE
EKSKQAEAEQ AARDEARRKR LAEAGGPAHE EEKPQTSAPP APPSPAAPLK SAMKKPAAPP
PRSKVAPPPP TSRHPSTPAA PAPPPSAPKI VAPPEEDPEE VELRQREEAA AKARADRRAR
LEQLQREEEE ERKQEEALLA ARQNRSKAPS PAVTAPATES APPPPAPPVP PAPAPPSETS
YNPFRKPGAA PGATPSPAGA AGGFNPFFKP SAAVSSGTAS PAAKSPEPAA SAPPPPPPPA
PPAPPAQPSK TAFRSPPSEP EWEDITEKEA DSDDSSDDET FSSRVGRQGL AQALFGNILG
SGGSSSPTTS RPGSTTPAAP AAPPAPKAPS AALSNLGGGD PGQSRGALLS AIQGGARLKK
TQTVDKSGPP GIGKVIGDSA PPSHINEQPR VVSPPPAPHS QEQDDEDDFQ SSRNANRQSV
DWYAGLAADS THPAAQHAEE STLTSTKEEE EPTSNGGYEQ VKENGGEADG LDEFDLSKTL
RVRSLYEFAG TRDVDLSFKE DVVLEAHPAK DASSAWWYGT LVKEGSKGWF PKDYVEELHV
TRAKALFDYP AGEEDQLPFM EGDVLEIVDQ SDQDWWKTEK AGVIFLVPAS YLEIQVGSES
EAKAPTDPIL DITPPPQEPI IKDTDKVEQL APRPTLSSAI QPRPTSMLSV TSSIGRSPSL
LSDDDDGSSS SGDSVLSWWS SDEEGSDVDE AESEDEEKEA ERKRREEDRQ KILSAAGLQI
KREPPPIPGP GSKVGRVVSR RRPPPGVPGK KRRKAPAIPR PSPGHPSKSL PAIPTSESPI
TSPTGTTTSK EPQDAYARYE AFLAQSQRPP NLRVDSSASG RARSQSLIQK LTTSQSISPQ
LTGPSASAST SSGNIPQPQS PTPSTALSLS GSTSGGKISG FFNKLMTNAN QPHHAKHPSI
SGPIISEMIS RPDTPSSTNA NNNGGGTPSD FGKTWGSLVE PSVLGTMSDR ERKRQEAIFE
FIATEAGYGR DLQLIVEVFY ASLIPLLDEK SLETIFANIE DILLFNTSFL SSLEDRQKSC
RLYIDWIGDI LEEHLANADV YTTYCVNQPA AIKLLQTLRE SNPDLAGHLA SLRENTPTLR
GLDLSHFLLS PMQRITRYPL LIKQIIHYTD ILDPSGEPNS DLPRVENALR MVEHIVGQIN
ESVREAEGEE RLKALSENLW IGGEGRLDLT APTALMGPRR LLKEGKVSKS KSGRRLTMIL
CNDIIVLLDG QDLYRMPLPL HEVQIRHGRD DTSFILKIDA RRGGDTVALR GVNAREVKDW
IQLITKARSG ALYARGGRK
//
