ID A0A1B9J198_9TREE Unreviewed; 2382 AA.
AC A0A1B9J198;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:OCF61548.1};
GN ORFNames=L486_01200 {ECO:0000313|EMBL:OCF61548.1};
OS Kwoniella mangroviensis CBS 10435.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1331196 {ECO:0000313|EMBL:OCF61548.1, ECO:0000313|Proteomes:UP000092583};
RN [1] {ECO:0000313|EMBL:OCF61548.1, ECO:0000313|Proteomes:UP000092583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10435 {ECO:0000313|EMBL:OCF61548.1,
RC ECO:0000313|Proteomes:UP000092583};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Kwoniella mangroviensis CBS10435.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10435 {ECO:0000313|Proteomes:UP000092583};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI669459; OCF61548.1; -; Genomic_DNA.
DR STRING; 1331196.A0A1B9J198; -.
DR Proteomes; UP000092583; Unassembled WGS sequence.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd00143; PP2Cc; 1.
DR CDD; cd17214; RA_CYR1_like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR013716; Adenylate_cyclase_G-a-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00789; Ad_cyc_g-alpha; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00364; LRR_BAC; 11.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000092583};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1644..1925
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT DOMAIN 2002..2138
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2273..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..165
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..825
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1945..1972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2273..2287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2382 AA; 258405 MW; 41CCDEF8ACE26BDB CRC64;
MSTNNDNSRI LHESPSSTYS ARLGLGPPIP TSSSKYGNSQ SEDVGVSEIH DSPEKKRRYL
EEENTPSAGA GQGGKLGSSP TEGRQGKRYS PRAKNGSSSA RMESSEISEK RRSRVLRTEQ
NATGSSTSPS ASPNIGSETI ILSGPTQGGD DDDFEDMEDD EDEDGRRDSI LDKPIPPRNP
TKVSPLAKRL GEEPPFMLPH PSRSTQTSQT SFPGVVIGSF AGGGGSTMTG FEGGMDDILD
PIANANSNNQ GRQGGTGANP STTTHTQAAP NIAPWLMDDS SPSSASSSTT VIHQPPLEIE
RTPSTRGPAA TLREKESSSR KASGVLNHFS SVPSLPKIRR QPTTDTLIQS ELGPSSRNTS
HSSMTTQILQ SSGQQTPLAS SSSSIIEGGS RQRNNSNDSL QTLSGNQRLA RDNSPKFDTT
TNQSSSSHSN KSHGTSRVGR FGSTASSTSG SGGTGNEKKK GFLGGLLKRR TGPSISLGSV
PDFQPPEAPN RGSTGSTSSK VSNSPSIGSM ISSTYGGLSP GDRMTSDSYG RNYRQGSNYI
SEGAISPLQE IAETPFHLDM NLDDMEGIVD PTKSGVQPTF ARPPPATHNS GTTATTESTA
GSMSVEDALA QTSSFATTVS GGESSGSGGS SGQLPATGRN LVGEAERVSG PFVRNPFSTG
SSVGSLDNTA KPSTPPSPHT LSPRHALPPT TQPRRPSQLR NVKMGSIDSE NSEPAEGATW
QHPIAPSWAA TGQSSQTVFN DPFGSAKSLP PIFDDNLAEA IPESRTPSES TIPDLTSSIS
ALPSHMGGGA ASAAAWAAPE SWGVEGDEEE SDETSSSDEG VDEQWEGDTS NVTAIANGRQ
SVGVESLRSP STASSAPKSP GMSPTGTKKP PPFGFKSTQP GSKTRSSSGR PSTGQGGKRG
KTASGRPSTA AKSKDGRPGT SGSVHGAAAV HWIRIYRSDG SYTLHQLPIN TTTAEFISIL
SGQNDAPPGK KITTSMKLYL RERGQDRLLL PSEKPIAIQH RRLLQAGYTE AEHPEEIGKD
DMAILCRFIY QTPALPIMNP EEESSYDSFE FIDVARRDLQ TIPIFLHLHA HNIIILNVSA
NPMTDIPLDF IQACTGLKEL RMSNMALKRV PNSIRASATL ARLDVSCNRI ADLESVPLNE
VETLVSLKVQ NNKLTSMPSY FAQMKALKYL NISNNKFETF PSVVCEMSNL VDLDVSFNNI
TELPSKMSDL KSLERLALFS NELTSFPPSF STLLNLRILD VRRNKLTDLT AVYALPNLAT
LQADYNNIVT LDAQIGANVR QFSVPHNSIT RFTLAPQPNM AMVTYNLTNL DLSHGKISTL
ADEAFSGLIN LVKLNLNFNQ FTRLPTTLDR LKNLEIFTCT DNMLSDLPLG LGKLQKLRVL
NLHNNNLKNL RSELWACGSL ETLNCSSNLL EGFEPFPEDW ETASGLPRSE LTDHYNGSPP
ITTSGRHLYL GDNRITDEIF HYVAHLPLIR TVNLSFNDIY EIPPDTIGHC SKLEHLYLSG
NKLTSLPAED LEKLVNLKTL HLNGNKLQTL PSELGAIKTL QHLDVGSNVL KYNIANWPYD
WNWNWNTALR YLNLSGNKRL EIKPTSAQEM NHASSFRKEL SDFTALTQLR VLGLMDVTLR
IPSLPDESEQ KRVRTSFSDI NNMAYGISDM LGHNEHLGMF DLVVPNFRGK DDECLFGMFG
RDAPTFNAGK IPKLLQELFA AQLVHHLGKL GKDEDLGDAL RRTFLNVNRA LFEGCFTPGT
TRKGSAQSMA SIDDMFRGWA PAVGSIYRTG SSGAVVYLSG KTLHVGNVGD ILVVVSRKGE
AELLSKKHDP TDREETARIR RAEAWVSTKG FVNDDKDIDI SRAFGYYHNF PAVNTSPEIR
TRPLTEQDEF VIIGNNALWS RCSYQTAVDI ARTEKHDPMM AAQKLRDFAI SYGADGSVMV
MVVNISDLFF GQSGHRPRGV PGSNVPSGVT DSTTGEIDST TATTSTNTAL AKRPMTRRRE
EVGDRTLNRL QREIEPPTGQ IAIVFTDIVN STHLWETNPG MPTSIKIHHN FMRRQLRLDG
GYEVKTEGDS FMVSFQSVTA ALLWCFNCQI GLLSQEWPRE LLEAQDGKVV YDSQGSLIQR
GLRVRMGVHW GSPECERDPI TRRMDYYGPM VNRAARINAS ADGGQLMASG DVINEITSVR
EYLETNDEEA LNELQGDIKR EILELRRIGL DIKDMGERKL KGLEVPEKLH LLYPKTLSGR
LEMSNDLRAE VEVNDARKRM IDLEQVKEFS LITLRLEALC SLGSTSISSL SPGSANSDIS
SLSPPGSPHE GQKEITGTKK GTVALPTPNL NLGPTIREDM NDEELMVIIE SLTGRCENAL
STLYLKQVGG FSTVMSALEK ATRIDSKLIT HALSLMNGAF GG
//
