ID A0A1B9R1L4_9VIBR Unreviewed; 281 AA.
AC A0A1B9R1L4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=S-formylglutathione hydrolase {ECO:0000256|RuleBase:RU363068};
DE EC=3.1.2.12 {ECO:0000256|RuleBase:RU363068};
GN ORFNames=A6E14_06180 {ECO:0000313|EMBL:OCH78095.1};
OS Vibrio genomosp. F10.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=723171 {ECO:0000313|EMBL:OCH78095.1, ECO:0000313|Proteomes:UP000093173};
RN [1] {ECO:0000313|Proteomes:UP000093173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9CSC122 {ECO:0000313|Proteomes:UP000093173};
RA Hehemann J.-H., Arevalo P., Datta M.S., Polz M.F.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine hydrolase involved in the detoxification of
CC formaldehyde. {ECO:0000256|RuleBase:RU363068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + S-formylglutathione = formate + glutathione + H(+);
CC Xref=Rhea:RHEA:14961, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:57688, ChEBI:CHEBI:57925; EC=3.1.2.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000080,
CC ECO:0000256|RuleBase:RU363068};
CC -!- SIMILARITY: Belongs to the esterase D family.
CC {ECO:0000256|ARBA:ARBA00005622, ECO:0000256|RuleBase:RU363068}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCH78095.1}.
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DR EMBL; MAJZ01000310; OCH78095.1; -; Genomic_DNA.
DR RefSeq; WP_065576460.1; NZ_MAJZ01000310.1.
DR AlphaFoldDB; A0A1B9R1L4; -.
DR Proteomes; UP000093173; Unassembled WGS sequence.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0018738; F:S-formylglutathione hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0046294; P:formaldehyde catabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000801; Esterase-like.
DR InterPro; IPR014186; S-formylglutathione_hydrol.
DR NCBIfam; TIGR02821; fghA_ester_D; 1.
DR PANTHER; PTHR10061; S-FORMYLGLUTATHIONE HYDROLASE; 1.
DR PANTHER; PTHR10061:SF1; S-FORMYLGLUTATHIONE HYDROLASE YEIG; 1.
DR Pfam; PF00756; Esterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU363068, ECO:0000313|EMBL:OCH78095.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000093173};
KW Serine esterase {ECO:0000256|RuleBase:RU363068}.
FT ACT_SITE 148
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT ACT_SITE 224
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
FT ACT_SITE 257
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR614186-1"
SQ SEQUENCE 281 AA; 31271 MW; 4F877D4B12D5A6E2 CRC64;
MTIENISQVK VSGGWHKQFT HHSTTLNCSM RFAIFLPPNA TKTSPVPVLY WLSGLTCTDE
NFMQKAGAFN KAAELGIAIV APDTSPRGSD VADDDSYDLG QGAGFYLNAT EEPWSRHYHM
YDYVSQELPK LIEQCFPVSS VKSISGHSMG GHGALTIGLK NSDQYQSISA FSPISHPINC
PWGQKAFNAY LGSNKDDWKQ YDACELLRDA PSSRPILVDQ GEADNFLAEQ LKPQELVEAA
KQHNSPLDLR MHAGYDHSYF FISSFIDEHL SFHAKYLINT N
//