ID A0A1C0AK04_9ACTN Unreviewed; 1029 AA.
AC A0A1C0AK04;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=uvrD {ECO:0000313|EMBL:VEP38554.1};
GN ORFNames=BCR15_06540 {ECO:0000313|EMBL:OCL32950.1}, TLA_TLA_00045
GN {ECO:0000313|EMBL:VEP38554.1};
OS Tessaracoccus lapidicaptus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Tessaracoccus.
OX NCBI_TaxID=1427523 {ECO:0000313|EMBL:OCL32950.1, ECO:0000313|Proteomes:UP000093501};
RN [1] {ECO:0000313|Proteomes:UP000093501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IPBSL-7 {ECO:0000313|Proteomes:UP000093501};
RA Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OCL32950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IPBSL-7 {ECO:0000313|EMBL:OCL32950.1};
RA Puente-Sanchez F., Arce-Rodriguez A.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000516347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:VEP38554.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TLA_E {ECO:0000313|EMBL:VEP38554.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; MBQD01000023; OCL32950.1; -; Genomic_DNA.
DR EMBL; LR214441; VEP38554.1; -; Genomic_DNA.
DR RefSeq; WP_068752057.1; NZ_MBQD01000023.1.
DR AlphaFoldDB; A0A1C0AK04; -.
DR Proteomes; UP000093501; Unassembled WGS sequence.
DR Proteomes; UP000516347; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000093501}.
FT DOMAIN 13..300
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 301..595
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1029 AA; 109538 MW; B8F3128C118F9B33 CRC64;
MNFRVLPPRR AVAPVLTLEQ RAALGGDGVR VVLGGPGTGK STVAAAAAAE RVRGGAELER
IIVVSHTRPA AQQLRRDITR RVDRAQTGAM VTTVHGLSLG LLRRFLPHED EGWRLLRAPE
QEQRIRELLD GQPVEAWPEA VRPALRTRAF ARQLREVLAR VRQLSLDPEA LESMAREGGD
ELFAAVARFL ESYLTVGDFS GTLDYAELVY RTRLLLTDSA VTDAVRASFD AVIVDDAHEL
DPAQVGLVTD LARAGLPLLA LGDPRQRIGG YRGASATALT DLGGLPGART LVLAAGHRAR
TEVAAALGAL QPRIAGPVDP PPPLPAGPGG RVAARVFDDA TAELAHVAAE IRSAVTVDGL
DWGDLVVVTR SGRSQLSGIA AELIRQGVPV EVSGDEIAVA EQPAAATLLL ALDVAARGGA
PAADEARLLL SSPLAGLDGV AQRALGRSLV ARHRALGTSA VLTARCLADA DLLTGIDTPE
ASAARRLGRL LAEAASLLEG SGEVQEALWL LWDRSLWPAR LRERALRGSR RADADLDAVV
ELFDLAARSG DMRGQAGAVT FIAEVAGQEI PADTGRESSV TGRGVRVVTA HRTRGLQWER
VWILGVQEGA WPRLTRAGLL LDPDRIGPEA LAPPGQASQL AAERRLFHVA CSRAVSELRV
SAVQGIEGEG GRPSRFLDEL GVAVERVYGR PRDLLSTASL VGDLRRTLAD ETAGPGLRRA
AALRLARLSQ VEAPDGAPGF PGAAPDGWWG LHPPSPGVSP DDGPVRITGS SLEMLLECPR
RWFLSRRAKA DSGRQSRASV GDVVHLLARH AAVDGLDAAG MRAKLAEVWT RIPFEAEWLS
TSERSEIEAA IDRFARYHEH SRDTLLAVEH PFRVSLTVAG QEVQLDGTVD RLERLPDGRL
RIVDLKTGRR LLKEADVVDH AQLGVYQLAA SLGAFEDVAP GARAVAPPAL LFLRGGEALP
LEVAQPSIDD SPRLPAEDPG DGPTWVHDRI RSAVEIVRGG RYDATECASC RYCPFAASCP
ALGRSGVAL
//
