ID A0A1C0AQR0_9ACTN Unreviewed; 344 AA.
AC A0A1C0AQR0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BCR15_13970 {ECO:0000313|EMBL:OCL36689.1}, TLA_TLA_00445
GN {ECO:0000313|EMBL:VEP39000.1};
OS Tessaracoccus lapidicaptus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Tessaracoccus.
OX NCBI_TaxID=1427523 {ECO:0000313|EMBL:OCL36689.1, ECO:0000313|Proteomes:UP000093501};
RN [1] {ECO:0000313|Proteomes:UP000093501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IPBSL-7 {ECO:0000313|Proteomes:UP000093501};
RA Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OCL36689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IPBSL-7 {ECO:0000313|EMBL:OCL36689.1};
RA Puente-Sanchez F., Arce-Rodriguez A.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000516347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:VEP39000.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TLA_E {ECO:0000313|EMBL:VEP39000.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; MBQD01000009; OCL36689.1; -; Genomic_DNA.
DR EMBL; LR214441; VEP39000.1; -; Genomic_DNA.
DR RefSeq; WP_068750390.1; NZ_MBQD01000009.1.
DR AlphaFoldDB; A0A1C0AQR0; -.
DR REBASE; 171432; M2.Tla7ORF13955P.
DR Proteomes; UP000093501; Unassembled WGS sequence.
DR Proteomes; UP000516347; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF07669; Eco57I; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000313|EMBL:OCL36689.1};
KW Hydrolase {ECO:0000313|EMBL:OCL36689.1};
KW Nuclease {ECO:0000313|EMBL:OCL36689.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000093501}.
FT DOMAIN 4..101
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 344 AA; 38478 MW; 44F8A45A471A204B CRC64;
MSKKFDVVIG NPPYQEEAQG GGTRDTPLYH LFMDAAHEVA KKAVLITPAR FLFNAGFTPK
AWNERMLADR RLTVPYYVPT SGELFPGTDI KGGIAVTSWA DDRDGEPIGI FTKYPELNTI
LHKVICSNHT SLESEVTSGR SYRYTQVMHD ENPSASGLMS SDAQFQVSTN AFDRVAFLFH
KDRPEDGEEY VRVYGRAQGS RTYRWIRRDY FAGPASFDRF KVALPKVNGT GALGEILADP
VILEPGVGTT YTFITIGSFD TAGEAEACLK YVKSKFARAM LGILKVTQDN KRHTWKHVPK
QDFTVASDID WTKSIPEIDL QLYAKYGLDS EEVAFIESNV KPMV
//
