GenomeNet

Database: UniProt
Entry: A0A1C0BSP0_9FIRM
LinkDB: A0A1C0BSP0_9FIRM
Original site: A0A1C0BSP0_9FIRM 
ID   A0A1C0BSP0_9FIRM        Unreviewed;       736 AA.
AC   A0A1C0BSP0;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE            EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN   ORFNames=A4S06_05070 {ECO:0000313|EMBL:OCN03734.1};
OS   Erysipelotrichaceae bacterium MTC7.
OC   Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae.
OX   NCBI_TaxID=1768196 {ECO:0000313|EMBL:OCN03734.1, ECO:0000313|Proteomes:UP000093409};
RN   [1] {ECO:0000313|EMBL:OCN03734.1, ECO:0000313|Proteomes:UP000093409}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MTC7 {ECO:0000313|EMBL:OCN03734.1,
RC   ECO:0000313|Proteomes:UP000093409};
RA   Whitehead T.R., Haley B.J.;
RT   "Genome Sequence of MTC7.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate;
CC         Xref=Rhea:RHEA:22088, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:142410, ChEBI:CHEBI:456215; EC=2.7.6.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001157};
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC       1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OCN03734.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LVZN01000067; OCN03734.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C0BSP0; -.
DR   STRING; 1768196.A4S06_05070; -.
DR   OrthoDB; 9805041at2; -.
DR   UniPathway; UPA00908; UER00884.
DR   Proteomes; UP000093409; Unassembled WGS sequence.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000093409}.
FT   DOMAIN          394..457
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          661..736
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   736 AA;  84415 MW;  7E8ED47EF21C7849 CRC64;
     MEDTLITFDE VMDEVKSYIK KEENLKLIQD AYEFAEEKHR PQKRKSGAPY VVHVLHVARI
     LADLRTGPST IAAGLLHDVI EDCGITKEEF IERFGQEVYI LVEAVTKIGS LKFSDEEEYL
     ASNHRKIFIA MANDVRVILI KLADRLHNMR TLQFMKPEKQ KKIAQETLDV YAPIAHRLGI
     SEIKNELEDL SFHYLNPEKY YEIAKLVENR KSERDEQVQE MIREFSGILD EHKLPFRMFG
     RSKHLYSIYK KMVNKNKRFE EILDLLAIRI VTNTEVGCYE ILGYIHAKYT PIPGRFKDYI
     AMPKMNMYQS LHTTIVGIEG NIFEVQIRTE MMDEIAERGV AAHWRYKENA NYVPNQQQKE
     IEEQLHFFKD FQLMSEDVNE DAKSFMNLIS KDIFEANVYV MSPKGKVIAL PSGSTPLDFA
     YRIHTEVGHQ TIGATVNGVL VPLNTQLKTG DVVNIKTNKN SKPSEDWLKI VKSNHAKNKI
     RSYFQRIKQE EKEEGAEKGK RMLEDELRKR GYEVKDYMAN RPLEHLAGQF KMHTLLDLYY
     AIFVKALPLQ NAIEKLTHQK AGAGETGAKD IEFKTHAPTK KELKEQSSSK YGVHVPGIDS
     IVISLAPCCS PVPGDDIVGY ITKGQGVKVH RKDCPNVQDL KERLIDVEWE GNRTVKNYPV
     HLLIHSTDRN FLLSDIVTVS SQSKVGMQHV DSKVNEDGIH ATTKLTVLVQ DLDQLQTLIT
     NLKKVTSVNS VERVVL
//
DBGET integrated database retrieval system