ID A0A1C0BSP0_9FIRM Unreviewed; 736 AA.
AC A0A1C0BSP0;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN ORFNames=A4S06_05070 {ECO:0000313|EMBL:OCN03734.1};
OS Erysipelotrichaceae bacterium MTC7.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae.
OX NCBI_TaxID=1768196 {ECO:0000313|EMBL:OCN03734.1, ECO:0000313|Proteomes:UP000093409};
RN [1] {ECO:0000313|EMBL:OCN03734.1, ECO:0000313|Proteomes:UP000093409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTC7 {ECO:0000313|EMBL:OCN03734.1,
RC ECO:0000313|Proteomes:UP000093409};
RA Whitehead T.R., Haley B.J.;
RT "Genome Sequence of MTC7.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate;
CC Xref=Rhea:RHEA:22088, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:142410, ChEBI:CHEBI:456215; EC=2.7.6.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001157};
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCN03734.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LVZN01000067; OCN03734.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C0BSP0; -.
DR STRING; 1768196.A4S06_05070; -.
DR OrthoDB; 9805041at2; -.
DR UniPathway; UPA00908; UER00884.
DR Proteomes; UP000093409; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000093409}.
FT DOMAIN 394..457
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 661..736
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 736 AA; 84415 MW; 7E8ED47EF21C7849 CRC64;
MEDTLITFDE VMDEVKSYIK KEENLKLIQD AYEFAEEKHR PQKRKSGAPY VVHVLHVARI
LADLRTGPST IAAGLLHDVI EDCGITKEEF IERFGQEVYI LVEAVTKIGS LKFSDEEEYL
ASNHRKIFIA MANDVRVILI KLADRLHNMR TLQFMKPEKQ KKIAQETLDV YAPIAHRLGI
SEIKNELEDL SFHYLNPEKY YEIAKLVENR KSERDEQVQE MIREFSGILD EHKLPFRMFG
RSKHLYSIYK KMVNKNKRFE EILDLLAIRI VTNTEVGCYE ILGYIHAKYT PIPGRFKDYI
AMPKMNMYQS LHTTIVGIEG NIFEVQIRTE MMDEIAERGV AAHWRYKENA NYVPNQQQKE
IEEQLHFFKD FQLMSEDVNE DAKSFMNLIS KDIFEANVYV MSPKGKVIAL PSGSTPLDFA
YRIHTEVGHQ TIGATVNGVL VPLNTQLKTG DVVNIKTNKN SKPSEDWLKI VKSNHAKNKI
RSYFQRIKQE EKEEGAEKGK RMLEDELRKR GYEVKDYMAN RPLEHLAGQF KMHTLLDLYY
AIFVKALPLQ NAIEKLTHQK AGAGETGAKD IEFKTHAPTK KELKEQSSSK YGVHVPGIDS
IVISLAPCCS PVPGDDIVGY ITKGQGVKVH RKDCPNVQDL KERLIDVEWE GNRTVKNYPV
HLLIHSTDRN FLLSDIVTVS SQSKVGMQHV DSKVNEDGIH ATTKLTVLVQ DLDQLQTLIT
NLKKVTSVNS VERVVL
//