ID A0A1C0ZTW6_9BACL Unreviewed; 308 AA.
AC A0A1C0ZTW6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=isochorismatase {ECO:0000256|ARBA:ARBA00012100};
DE EC=3.3.2.1 {ECO:0000256|ARBA:ARBA00012100};
GN ORFNames=A8709_07585 {ECO:0000313|EMBL:OCT11518.1};
OS Paenibacillus pectinilyticus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=512399 {ECO:0000313|EMBL:OCT11518.1, ECO:0000313|Proteomes:UP000093309};
RN [1] {ECO:0000313|Proteomes:UP000093309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC13222 {ECO:0000313|Proteomes:UP000093309};
RA Zhang J., Zhang X.;
RT "Paenibacillus oryzae. sp. nov., isolated from the rice root.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-
CC dihydrobenzoate + pyruvate; Xref=Rhea:RHEA:11112, ChEBI:CHEBI:15361,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:29780, ChEBI:CHEBI:58764; EC=3.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000128};
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|PIRSR:PIRSR001111-50};
CC Note=Binds 1 phosphopantetheine covalently.
CC {ECO:0000256|PIRSR:PIRSR001111-50};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCT11518.1}.
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DR EMBL; LYPC01000028; OCT11518.1; -; Genomic_DNA.
DR RefSeq; WP_065858633.1; NZ_LYPC01000028.1.
DR AlphaFoldDB; A0A1C0ZTW6; -.
DR STRING; 512399.A8709_07585; -.
DR OrthoDB; 257098at2; -.
DR Proteomes; UP000093309; Unassembled WGS sequence.
DR GO; GO:0008908; F:isochorismatase activity; IEA:UniProtKB-EC.
DR CDD; cd01013; isochorismatase; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016291; Isochorismatase.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR43540:SF3; ENTEROBACTIN SYNTHASE COMPONENT B; 1.
DR PANTHER; PTHR43540; PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR Pfam; PF00550; PP-binding; 1.
DR PIRSF; PIRSF001111; Isochorismatase; 1.
DR PRINTS; PR01398; ISCHRISMTASE.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Phosphopantetheine {ECO:0000256|PIRSR:PIRSR001111-50};
KW Phosphoprotein {ECO:0000256|PIRSR:PIRSR001111-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000093309}.
FT DOMAIN 219..296
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT MOD_RES 257
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001111-50"
SQ SEQUENCE 308 AA; 34872 MW; 42BE93DA48D12F2C CRC64;
MALPKIQPYS MPVAADLPQN RVAWTPDPNR AVLLIHDMQQ YFLNAFTLGD SPVNELLTHI
RALREQCRKL GMPVVYTAQP DGQTPEERGL LLDFWGEGIN DHPELKHVVP ELAPEEGDIV
LTKWRYSGFR KTNLAEIMQE SGRDQLIVTG IYAHIGCLMT ACEAFMQDIQ PFFVADAVAD
FSLENHQMAI TYAAQRCAVT LTTERVLTYL APAQSQAEEG SSFNIEKIRE QVAGLLNEAP
ESITDEEDLI NDRGLDSIRI MSFVEQWRRE GVEVTFVELA ERPNLASWWQ LIASRLRVPV
PNLDYFGR
//
