ID A0A1C1CKA1_9EURO Unreviewed; 1514 AA.
AC A0A1C1CKA1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN Name=VPS10 {ECO:0000313|EMBL:OCT48935.1};
GN ORFNames=CLCR_04501 {ECO:0000313|EMBL:OCT48935.1};
OS Cladophialophora carrionii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=86049 {ECO:0000313|EMBL:OCT48935.1, ECO:0000313|Proteomes:UP000094526};
RN [1] {ECO:0000313|Proteomes:UP000094526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSF {ECO:0000313|Proteomes:UP000094526};
RA Teixeira M.M., Souza R.C., Almeida L.G., Vicente V.A., de Hoog S.,
RA Bocca A.L., de Almeida S.R., Vasconcelos A.T., Felipe M.S.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCT48935.1}.
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DR EMBL; LGRB01000011; OCT48935.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C1CKA1; -.
DR STRING; 86049.A0A1C1CKA1; -.
DR VEuPathDB; FungiDB:CLCR_04501; -.
DR VEuPathDB; FungiDB:G647_02973; -.
DR eggNOG; KOG3511; Eukaryota.
DR Proteomes; UP000094526; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000094526};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1514
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008650857"
FT TRANSMEM 1366..1387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1419..1446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..682
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 718..1355
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1514 AA; 169283 MW; CB9440A05E4872E2 CRC64;
MIIRSFCRRA VASSLALLLL LASCPPPAQA KKDGPTISST IFDNPLENVF YFDDSDVVLG
YDGETGTVWR SPDAGETWKE VNDQGQSGNV LDVYQHPWDN QRAYIIGLDS EHWVTTDTGK
TWTSFSVDPD DNLARFRNAP LSFHGRDPSR VIWNAEHCVG LACMERAFYT DDDFETINPL
GSMTRGCQWA VSTPEFAREI APEVRDRIFC IVEGLYSPWP KDNRLLVSDD FFTRDQLEPA
LDDGRAVTGI ISMAAVKGFL VAAAKSEGTD ELALYVTTDG AQWHRAEFGQ HRISEDAYTI
LESTNYSLQI DVLGSRPTNP TGYLFTSNSN GTYFTRNIDH TNRNIFGNVD FEKVQTIQGI
VMVNTVQNWK EVEGSTIPQK EIVSQISFDD GRTFQDLKVG DKRLHLHSVT DARQAGRIFS
SPAPGIVMGI GNTGKFLKDY EDGDLFVSDD AGVTWIEGLD GAHLYEFGNQ GAVIVAVDDE
EPTSHIRYSI DHGKTWKKAD LGEKVRARFL TTVPDSTTLK FLMMGAKGTG SKTEWIMFKI
DFEGLHERAC VDKDFDRWPA RVDKDGKPSC LMGHKQFFRR RKADAECFID EEFQDPVPEF
EPCVCTKADF ECDYNFVRTE DRKDCVPADG VTLPVPEGAC KNEKDTFKGP SGWRLIPGNE
CVRKGGDELD LEIERPCSDS VKRPASGEIV VEKTNFNADR FSEWYYLERG DTAIGDDETI
VMRTSEQDIF LTRDHGKTWL PILKGEPITA IAPNPQHHDA VFFLTGSKEV HYTIDRGDRF
DKFSAPERPS TLRLPTMRFH PEYKDWLLWS GAVGNDDHTN IWLSKDRGDR WDVMVRYGRK
CEFMTREGRA HGDQLIFCAQ YEDENPTKNL MLISSDNFFA DSTVHFPDIL DFATMAEFII
VAAKTEDQQS LRVDASVDGR TFAPAEFPRN FQVKHQQAYT VLDSSTHAVF LHVTVNAVQD
HEYGAIIKSN SNGTSYVYTL GGVNRDTEGY VDFEKMQGLE GVAMVNVVAN RDETNDGEKK
KLKSMITHND GAEWAFLPPP KQDALGNNYP CVGEANKATA KCSLHIHSYT ERGDKSATFS
SPSAVGIMMA VGNVGDYLVR KDDEITDTFI TRDAGITWQS VKKGSYMWEY GDQGSIIVIV
KESQPTKSLF YTLNEGLTWK EFEFSPNVEM QIDAITTVPS DTSRAFLLWG RELGSQAKRG
IFTVHVDFSG LKERERKCEL DEKDPEKGDY TLWEPKHPMQ DSNCLFGHVA RYHRKRVDRD
CYNGKKIDHL HSIARNCSCT RQDFECDYNY EIQADGTCQL VPGLQPADHE ANCRDNPDQV
EFWYPTGYRR IPLTTCQGGR ELDKLESRPC PGHEEEYEKK HGISGAGLFF AIFVPIALAI
GIGYWAYTKW QSGGGGFGQI RLGEGFSASA GGAGGGDAWW IKVLVVSVSG VVAVAKATPL
LVMSLFRSAR GYMPLGGGSS GGGGRFGVGR GTNVGGYGAP YRSRDAFARR GQDYSQVVED
DELLGDGLDD EEEV
//