ID   A0A1C1D149_9EURO        Unreviewed;       713 AA.
AC   A0A1C1D149;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=N-acetylated-alpha-linked acidic dipeptidase 2 {ECO:0000313|EMBL:OCT54446.1};
GN   Name=NAALAD2 {ECO:0000313|EMBL:OCT54446.1};
GN   ORFNames=CLCR_00787 {ECO:0000313|EMBL:OCT54446.1};
OS   Cladophialophora carrionii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Cladophialophora.
OX   NCBI_TaxID=86049 {ECO:0000313|EMBL:OCT54446.1, ECO:0000313|Proteomes:UP000094526};
RN   [1] {ECO:0000313|Proteomes:UP000094526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSF {ECO:0000313|Proteomes:UP000094526};
RA   Teixeira M.M., Souza R.C., Almeida L.G., Vicente V.A., de Hoog S.,
RA   Bocca A.L., de Almeida S.R., Vasconcelos A.T., Felipe M.S.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OCT54446.1}.
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DR   EMBL; LGRB01000004; OCT54446.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C1D149; -.
DR   STRING; 86049.A0A1C1D149; -.
DR   VEuPathDB; FungiDB:CLCR_00787; -.
DR   VEuPathDB; FungiDB:G647_01707; -.
DR   eggNOG; KOG2195; Eukaryota.
DR   Proteomes; UP000094526; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094526};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..713
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008651201"
FT   DOMAIN          165..235
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          348..538
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          602..711
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
SQ   SEQUENCE   713 AA;  77602 MW;  DCFD62762E439A30 CRC64;
     MKVNKALPLL VLQATSVLAH TGEHFHPRVF DPRQALSKRQ EAPFPPILEP NEAILLNSFD
     NATIEGWSYY YTHGLHLAGT NKSQAQWTAD RWSEFGFTSG LASYYVYLNY PVSHSLTATF
     ANGSAYTPQL EEEVLAEDEV TSYPNRVPIF NGYSPSGNAS AEYVYVGRGQ KVDFERLRAL
     GVPLEGKIAL SRYGGPFRGL KVKNAQDYGM IGVILFTDTA DDGNITEANG YAAYPHGPAR
     NPTYVQRGSV EFVSTYSGDP DTPGYASKLD SPRADRSVVI PQIPSLPISW KTAQPLLQAL
     DGHGVDGKTV NRTNWVGKLN ATYSTGPAPG VTISFSNVAR DEITWIWNSI GIINGTNQDE
     VVILGNHRDA WIVGGGSDPN SGSAVLIELA KAFGALLKTG WKPKRTIILA SWDAEEYASV
     GSTEWVEEYI PWLKDSAIAY LNVDQAVAGP DPALSATPEL HDVVAESLKK VVYPYHGYSN
     LTLYDVWYGL SDGEFEVLGA GSDYVAFLHN GIASLDTGAG QGPNDPIYHY HSSYDTFHWM
     KTFGDPYFTT HKAVGQHLAI LVYHLANDDI IPFNVENYGI HLTSYLNDLR DLVESENATS
     AVDLSPLEDA IATFNASAAA ITAFIQTSTT EADFKIINSK LRDFSRGFVS QGGLPTREFY
     KHVAFAPGLD TGYAPVTWPG VTEAVQDGNL TLASSWVLKS ARAVEVAAAI LAP
//