ID A0A1C1D198_9EURO Unreviewed; 1920 AA.
AC A0A1C1D198;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=stt4 {ECO:0000313|EMBL:OCT54448.1};
GN ORFNames=CLCR_00751 {ECO:0000313|EMBL:OCT54448.1};
OS Cladophialophora carrionii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=86049 {ECO:0000313|EMBL:OCT54448.1, ECO:0000313|Proteomes:UP000094526};
RN [1] {ECO:0000313|Proteomes:UP000094526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSF {ECO:0000313|Proteomes:UP000094526};
RA Teixeira M.M., Souza R.C., Almeida L.G., Vicente V.A., de Hoog S.,
RA Bocca A.L., de Almeida S.R., Vasconcelos A.T., Felipe M.S.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCT54448.1}.
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DR EMBL; LGRB01000004; OCT54448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C1D198; -.
DR STRING; 86049.A0A1C1D198; -.
DR VEuPathDB; FungiDB:CLCR_00751; -.
DR VEuPathDB; FungiDB:G647_01709; -.
DR eggNOG; KOG0902; Eukaryota.
DR Proteomes; UP000094526; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OCT54448.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000094526};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1326..1512
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1635..1904
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1622..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1920 AA; 214951 MW; 5034556A2BCEA3EE CRC64;
MPSLKAAGNG GIFDGVLRSI APTSRVPMSH RELDVLLALC ASAHDLHDLS HADRLVKQLT
AYLPESYSQL FSPSPFIQEI RPAPWTALTY QLTTALLVLG LRFPPLKEAV SASIKEYVQN
WSQSASALTS LNVGEQDEEQ GNETQEIAAA TVSLIGFLDA AAIHENFWTA YERVELIRNL
KEALSERFLI ALETASSAIR NSASSEAGER DWRKYLRRFA AQGLPVGAMM LQKGFVKLVL
ACTARMLCDE HTVQCGDILD QYIAGTHINR ARDDSITDDM IEYLVDTITE QMRVLEDGSD
YLQLSSVWQQ RLAFSVKAYA LEAYLHCLVL DDDIADAEDL AAWLEDSIAN QVQMTDSDLA
DIVLKSLAVV AKYVPEGANN YARILLRFIV RGTSRPDAVT IAAQSLSHIL RMLSQDAVIT
TIYSLGNVLS SQTGAEKTHQ LHGTAEANGH GGSMSSTTRL RTGSVISLSL SGDEETSLVC
GNVAHAIVVI ATECNDSKII ALVQMMMLQK VGRISVVVDA HIVQEAAKLS ISGKENEFKT
LLKLYTRLHH EAVVQNNTPL IEAVRNAQEY LALNLDNRSP LFKIYAMQLL ERILSKGDVV
EGEFKQSAEV EQAAKEIAPL LKPLSILASR KPALTIESTL AEDTDILAMA REVWYNVAVH
GITLQSRIGQ QHYEELRLLA MNSMPLVDDD RAELLESDVE INTVLRRGMN PQHMQAQKKA
LIAVIPDKES EIGKLSYQKV VFLNAVFLVE SLRASSGSCA EILDYFVDPS TQTSHMGACL
SSIANKVVDR YTQKAVSAKE DDFSAPYVSR QLARILSGCC HRSSKMQEVA RAAANHIITF
APSALCQKSA LFALLELLSL MWSSCLDADT DEYEWRPTLT STRGKITVEL SDDYAFRRRT
EQNLHSDARK WVTMVMGVAP LDVKGLLQTY LSEFDDTGAY GHISLGRSFA LEMGSMIPPM
DYRLNALDHK NESANINMAS DFIAQYTTRQ EYRFTGVPDH QRENTYIDDA TGRRSSMGRA
AADSTSILHD ALVDLQNRIL QKAHVRNSEV KDVLRRAAAL LCQSKKSQTA IVHLLVNIPL
AIFTKESIKL GISLWLGVIH ENIRMEPRIL TEVAQAWERT IDRRQGIFNP KFKHIDPFYV
KEEFAPSDRA ALQKEAQTAH NTISPHFRLL QFFESHFNAI RLGSANTQRT FIRMLERTLR
GFLHVHGHPL LRDLQFHVVL FALRVLKLGT CLNKLSRWKL KDLILSVGLQ WFAKPPCWSF
GGNRLQLKAE IRVTQDVLAQ LQASRGPILP ASATRKDPQQ KQELLEALLT SEITRLGVWL
SPLAHGGQAA QLDNQIAAFV RVAWAEDPAL AIQLVSRFTN EQTRRDARFL LLNQPEKALH
EANAVDLVLG DGLSSDLSFQ LKYLLYWNPV NPIQAVTYFM PAFGNHPFIL QYAMRAVESH
SVDVTFFYVP QIVQSLRYDT LGYVERYIIE TGKFSQLFAH QIIWNIKANA YKDEDSQIPD
PVKPTLDKVM DSLISSFSGA DKDFFEREFA FFSEVTDISG KLKPFIKKSK PEKKAKIEEE
LRKIKVDVGV YLPSNPDGVV VGIDRKSGKP LQSHAKAPYM ATFRIRKKKE TPTEEMNELI
ESAQQEQTQK HARRGHSRRN TSDISSTELA DTNPSTYEVW QSAIFKVGDD CRQDVLALQM
IAAFRGIFNS VGLDVYVFPY RVTATAPGCG VIDVLPNSIS RDMLGREAVN GLHDYFITKY
GGEHSVRYQE ARSEFVKSMA AYSVITYLLQ FKDRHNGNIM VDDKGHILHI DFGFCFDIAP
GGVKFERAPF KLTPEMIAVM GGDDPATSQP YRWFEELTIK AFLASRPYCD KLSHLVSLML
DSGLPCFKPE TMRNFKNRFV LERSEREAAE FMLGCIKKSA ANVTTRVYDE FQLITNGIPY
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