UniProt: A0A1C1X7A2

Database: UniProt
Entry: A0A1C1X7A2_9PEZI

LinkDB:  A0A1C1X7A2_9PEZI 
Original site:  A0A1C1X7A2_9PEZI

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Ontology (6)   
   GO (6)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (42)   
   InterPro (23)   
   Pfam (11)   
   PROSITE (2)   
   SMART (6)   
All databases (50)   

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ID   A0A1C1X7A2_9PEZI        Unreviewed;      2624 AA.
AC   A0A1C1X7A2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Polyketide synthase 30 {ECO:0000313|EMBL:ALP31870.1};
GN   Name=PKS30 {ECO:0000313|EMBL:ALP31870.1};
GN   ORFNames=DHEL01_v208016 {ECO:0000313|EMBL:POS73579.1};
OS   Diaporthe helianthi.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Diaporthales; Diaporthaceae; Diaporthe.
OX   NCBI_TaxID=158607 {ECO:0000313|EMBL:POS73579.1, ECO:0000313|Proteomes:UP000094444};
RN   [1] {ECO:0000313|EMBL:ALP31870.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=7/96 {ECO:0000313|EMBL:ALP31870.1};
RA   Maimone Mancarello A.B., Pane C., Ruocco M., Cacciola S.O., Firrao G.,
RA   Magnano Di San Lio G., Baroncelli R., Vannacci G., Vergara M., Scala F.;
RT   "Dhpks1, a gene encoding a polyketide synthase of the phytopathogenic
RT   fungus Diaporthe helianthi is required to trigger sunflower stem canker
RT   toxin-mediated disease.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:POS73579.1, ECO:0000313|Proteomes:UP000094444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7/96 {ECO:0000313|EMBL:POS73579.1,
RC   ECO:0000313|Proteomes:UP000094444};
RA   Baroncelli R.;
RT   "Polyketide synthases of a Diaporthe helianthi virulent isolate.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KR153156; ALP31870.1; -; Genomic_DNA.
DR   EMBL; MAVT02000771; POS73579.1; -; Genomic_DNA.
DR   STRING; 158607.A0A1C1X7A2; -.
DR   InParanoid; A0A1C1X7A2; -.
DR   OrthoDB; 5396558at2759; -.
DR   Proteomes; UP000094444; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF28; SYNTHASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000094444};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          26..446
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2540..2616
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1643..1682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2624 AA;  282697 MW;  8D0C86684AF87AC3 CRC64;
     MRSHTSETGG GDGTSHAIPP TDPKTASPIA ICGMALRLPG GLESPQQFWD FLVNKGDARG
     RVPESRYNIS AYYSRSGRPG TIGTEHGYFL SDDVQLGALD AGRFSISRAE LECADPQQRR
     MLEVVQECLD DAGEVGFRGA QVGCYMGSYG EDWLEMQNRD PQQSGIYRLD GYGDFMLSNR
     ISYEMDLRGP SMTVRTACSS ALVGLHEACL AIQQGHCKSA VVGGANLIMA PGAMASMTEK
     GVLSPDGSCK TFSADANGYA RGEAVTAIYI KPLDAAMRDG NPIRAVIRSC MSNNDGKTPG
     ISCPSTDSQV AMIRDTYSEA GITDFSQTAF VECHGTGTAV GDPIEANAVA RVFGDSGVFI
     GSVKPNLGHS EGASGITSVI KAVLALENRT IPPNIKFSSP NPAIPFRERR LAVPLEPTPW
     PESKSERVSV NSFGIGGSNA HVVLDSARSF NLPAPIATAR AAAAKADPRL AAGPHLLLMS
     AASAASLKQV SLNLQAWLTD EKHGPFGEQK QLLLQDVAYT LAHRREHLSH RAFVVSRRDQ
     PVVASSPGKK ANTARPPNIV MVFSGQGAQW ARMGRELLLR SDLCFQSSIE ALDRCLQDAQ
     LRSSDVCHGD AAGTASKPGD PWSLKEELLK PARTSRVQEA EFSQPLCTAV QIALVDLFAS
     VGVEPVAVVG HSSGEIAAAY ATGALTAREA IITAWQRGQA AKSQTRPGAM AAVSLGWDQV
     KTFLPTSDPP GVVVACENSP RSVTLSGDAV DVEAAVSKIK QAHPDVTARL LKVDKAYHSY
     HMREVGHEYC SSMEKVLGAG KRPLRPFFST VTARLEEGVL DAAYWRKNLE SPVLFKSAVS
     LVLENIDNVA FLEIGPHSTL AGPLRQTTIA WQDTTVNTTT SPPYISALTR SEDSAESFLT
     AMGKLFELGV PIDLGALMPT GSCLPDLPRY QWDHSGGDHW RESRMSHEWR CREHAAHPLL
     GARQLESTSL EPSWRNMLHV DKVPWLRDHR IEGLLIFPCA GYVAMAGEAI SQAAARTAGF
     SLRNVVISSA LVINEGVPVE LVTTLRPYRL TDSLDSQWWE FSISSHNGHV WTKHITGQVS
     GCDVDVDVDV NDDNTTAVGS VPLPRAVEVE KYYSILDRAG LQFGPHFRRL ADIRTGTTQQ
     VATARVAINT TDASLDDGDD YHLHPTAVDA CIQTLFLAAL KGRMDAKHCR AVPTKIKKLS
     MRRPIDCVED SKMTVSASAT VTAGSGDIVG LAQQCVVNGR VALHIEGMTI SPLEEAEDAG
     SGGGLDFVGS DGLRTTARTL WGPHVDFLDA AKLIRPSIPR HLYAPTLDEL TLLAQIYAQR
     RMAESCGSRG GLPHMVKYRL WVDTQVQQHM QPSGLDSCTA ALQVLGDAAL ADKMTDIVNR
     LSDTPVAACA TAVQKVALNM SGLYVGDTEA LEILLADDTL TQVYIATDAC DRSEFVRHLA
     HSKPNLRILE IGAGTGASTM SMLKHLVLPG ADGLDGPGGH PLYSKYTFTD ISSAFFVSAK
     ERFKGRPNIE YRTLDISKDP AGQGFGAADR YDLVIATNVL HATPRLGETL RNVQCLLAPG
     GRLLLHEIYS RSTWPNFVFG TLPGWWLGEG DGRPQQPCVD PARWEEELTR SGFSGLDALV
     FDADEPYQLN AIMVAKPRLQ LAGEEGSNKG NKSVTLLCDD DDDDDQERNS KNNSNGKPDD
     SFASDFLVQQ LELRGYNVTR RRLSDELPTG PLDDMISLLD LGPRGPFFKD ISEVRFVAFQ
     RLLEKLASSS SSSSSSAGDG RRPCMLWVTR PCQVRCRDPG YAQVIGAART IRTEMLLDLA
     TCEVDDVVGG CAPSSSPSPS PSLGRVIDVF TRFRERGSEV QDDGSLDPDY EFAIVDGTVM
     VGRAYPFSLA DDQVLLSAAE GAGAAGLSLG MKRPGRLATM GWYPRVAREL QGDEVEVEVH
     AIGLNFKDVL CALGVVPFPK GGLGSESSGV VRRVGPEVKD LCIGDRVFLM ADGSFATHVI
     GIERMCERIP ATMPFEEAVT MPAVFTTTVA ALLNIGRLEK GQTVLIHSAC GGVGLAAIQL
     ARMVQAEIYA TVGSEDKIKY LTDTVGLPRN RIFNSRDSSF VQGLMRETNG RGVDLALNSL
     SGELLHATWH SVAEFGRMVE IGKRDILGGG KLDMDVFLTN RGYTCFCLDH LAQNRPAAFK
     ELLRWVRKHL EEGTIQPIPC AKVFDASSLQ EALRHMQKGQ HIGKIVISMR DAEGAVKINT
     APIKPAPKLQ LDSSASYMLV GGLGGLGRAV SRHLVDHGAR RLVFLSRSAG SRPEDADLSR
     ELESMGCEVI LVRGSVTNAA DVTRAVQQAP NLRGVMQCSM VLSDQAFPRM SLDEWNTAVA
     PKVMGTWNLH NATVSAGADL DFFLLFSSMS GLTGQAGQAN YAGANTFLDA FVQFRNGLGL
     AASAIDIGAV QDVGYVSQDP ALLKRMMLAS AHGITEPELL EALTAAMLSG PRPQCGKASL
     GTPAKETAFE DRNTFVLGLG TKIPLSSPDS RAFWRRDRRM AVYHNSSRAA VSDGASNSDG
     LKAFLARARS DAALLQAPDT AAFLAREVGR KLFSFLLRPE EELNTSVPLS QLGMDSLVGV
     EMRSWWRQAF GFDITVLELL GAGNLSALGS HAAEGLYKLL HGKN
//

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