ID A0A1C2GLC7_9SPHI Unreviewed; 473 AA.
AC A0A1C2GLC7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Glycosyl hydrolase family 43 {ECO:0000313|EMBL:OCX52262.1};
GN ORFNames=BEL04_12355 {ECO:0000313|EMBL:OCX52262.1};
OS Mucilaginibacter sp. PPCGB 2223.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1886027 {ECO:0000313|EMBL:OCX52262.1, ECO:0000313|Proteomes:UP000095113};
RN [1] {ECO:0000313|EMBL:OCX52262.1, ECO:0000313|Proteomes:UP000095113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PPCGB 2223 {ECO:0000313|EMBL:OCX52262.1,
RC ECO:0000313|Proteomes:UP000095113};
RA Seilhamer J.J.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OCX52262.1}.
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DR EMBL; MDJS01000002; OCX52262.1; -; Genomic_DNA.
DR RefSeq; WP_066004231.1; NZ_MDJS01000002.1.
DR AlphaFoldDB; A0A1C2GLC7; -.
DR STRING; 1886027.BEL04_12355; -.
DR OrthoDB; 9803461at2; -.
DR Proteomes; UP000095113; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF5; ENDO-ARABINASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|RuleBase:RU361187, ECO:0000313|EMBL:OCX52262.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000095113}.
FT DOMAIN 375..473
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT ACT_SITE 47
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 214
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 168
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 473 AA; 53158 MW; F0F49B3CA40F4259 CRC64;
MPSKLNFLKP ERTKVIAYIA FSLCINHLKA QTNNPFGHPL IPDMIADASI QVIDHTFYCY
ATTDGYDNGL KTSGPPVVWK SKDFVHWSFS GCYFPSAAKQ KYWAPSKVIA ANAKYYIYPT
VNGFMYAAAA NSPDGPFELV IKPDTFYNPY TSSTLLKPVK ARPPAGIDAE VFVDDDKQAY
LFWQRRKAAR LYPDMITVDT NSITIPTPRS GYSEGPIFFK RKGIYYYLYT LGGAENYQYA
YVTSKVSPLG PFDFPAKNDI VTTTNHELGI YGPGHGCVFN LPGTDDYYFA YLEFGRGSTN
RQTYVNRLEF DDAGAIKPVQ LSKDGVGALF KTKWPEPKKV FNATSSSTRA DLKIKPEGDT
SLHRKESFFP LFAFDGSNGS RWMAAPGDTE NWLMADLGKP VKISSSEVYF VRPTAGHSYL
LEYSVDGKNW TPCGGRSEIQ MVSPHTDKFD IKARYLRVKI LNGIKGVWEW DIY
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