ID   A0A1C2IAU2_ACITH        Unreviewed;       886 AA.
AC   A0A1C2IAU2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=DOD-type homing endonuclease domain-containing protein {ECO:0000259|PROSITE:PS50819};
GN   ORFNames=A6P07_19980 {ECO:0000313|EMBL:OCX67511.1};
OS   Acidithiobacillus thiooxidans (Thiobacillus thiooxidans).
OC   Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=930 {ECO:0000313|EMBL:OCX67511.1, ECO:0000313|Proteomes:UP000094893};
RN   [1] {ECO:0000313|EMBL:OCX67511.1, ECO:0000313|Proteomes:UP000094893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A02 {ECO:0000313|EMBL:OCX67511.1,
RC   ECO:0000313|Proteomes:UP000094893};
RA   Zhang X., Feng X., Tao J., Ma L., Xiao Y., Liang Y., Liu X., Yin H.;
RT   "Comparative genomics of the extreme acidophile Acidithiobacillus
RT   thiooxidans reveals intraspecific divergence and niche adaptation.";
RL   Int. J. Mol. Sci. 0:0-0(2016).
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC       chain family. {ECO:0000256|ARBA:ARBA00010406}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OCX67511.1}.
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DR   EMBL; LWSA01000348; OCX67511.1; -; Genomic_DNA.
DR   RefSeq; WP_051488096.1; NZ_LZYI01000193.1.
DR   AlphaFoldDB; A0A1C2IAU2; -.
DR   STRING; 930.GCA_002079865_00432; -.
DR   Proteomes; UP000094893; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   Gene3D; 3.20.70.20; -; 1.
DR   Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   InterPro; IPR013346; NrdE_NrdA_C.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR039718; Rrm1.
DR   NCBIfam; TIGR02506; NrdE_NrdA; 1.
DR   PANTHER; PTHR11573; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; 1.
DR   PANTHER; PTHR11573:SF6; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT; 1.
DR   Pfam; PF14528; LAGLIDADG_3; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   PRINTS; PR00379; INTEIN.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR   SUPFAM; SSF55608; Homing endonucleases; 1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS00089; RIBORED_LARGE; 1.
PE   3: Inferred from homology;
FT   DOMAIN          90..245
FT                   /note="DOD-type homing endonuclease"
FT                   /evidence="ECO:0000259|PROSITE:PS50819"
FT   REGION          249..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..264
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  99214 MW;  B45C2632D7B654A1 CRC64;
     MTYAQNDPMV EIRIKHSLMP IQVTTGHPVL AIQNVALGET SARTLKRLEN GKRSPTWVDA
     GNLQVGDYVA QTIPGEVIPV AGFTDEEAYL YGIMLGDGHV AQKQGVNREY GVTLNATSKA
     HLAQFVRQYL LEHDIHFWEN SAHGSVVQLR WAYGRTCLRD AVNGQFVAGE EAPVLPFDFA
     DLYNAKGEKK VSARFLHLPE SQTLAILKGL LQTDGHLARG KEIFFTTASL TLAENVRYLL
     LRLGIPSSGR QRDRRDEVHT ATRKDGSQDT LSGGLSYELR IPAYPKIAAL LGCEPVQKHM
     ALRIGRWLFS RVTSIADITP VPFVCDLKVE GDESYMTTAF LAHNGGKRKG AVCAYLETWH
     LDIEEFLELR KNTGDDRRRT HDMNTANWIP DLFMKRVMDN AEWTLFSPNE VPDLHELYGT
     RFEERYAEYE SMAENGQLEQ FKKVPAVELW RKMLTMLFET GHPWITFKDP CNVRSPQRHA
     GVVHSSNLCT EVTLNSNDEE TAVCNLGSVN LMQHLITNPV ISEHGDELET EDWPYDQLRE
     SMTPVNALRH INKEALFETV GTAIRMLDNV IDINFYPTRK ARNANMRHRA IGLGVMGFAD
     ALQALRIPMD SEAAVTFAGV SQEVISFAAI QTSADLAVAR GSYSSFQGSD WSRGILPINT
     VQRLETERGM ELLTAQQPSA IDPDLWDAVR VRVQHGIRNS NIMAIAPTAT ISNIVGVSQG
     IDPIYQNLYV KSNLSGEFTV VNTQMVADME KLDLWDDVMV NDLKYFDGSL AHIDRIPSWM
     KRLYATAFEI DPLWLVRMTA ERQKWIDQSV SLNLYMAKPS GKALDNLYKQ AWMYGLKTTY
     YLRTMGATSA EKSTVTEGTL NAVQGGTPAP AIKACLIDDP TCEACQ
//