ID A0A1C3E7Z2_9GAMM Unreviewed; 845 AA.
AC A0A1C3E7Z2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Peptidase M4 family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=A8L45_22370 {ECO:0000313|EMBL:ODA29344.1};
OS Veronia pacifica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Veronia.
OX NCBI_TaxID=1080227 {ECO:0000313|EMBL:ODA29344.1, ECO:0000313|Proteomes:UP000094936};
RN [1] {ECO:0000313|EMBL:ODA29344.1, ECO:0000313|Proteomes:UP000094936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAIM 1920 {ECO:0000313|EMBL:ODA29344.1,
RC ECO:0000313|Proteomes:UP000094936};
RA Gomez-Gil B., Enciso-Ibarra J.;
RT "Genomic Taxonomy of the Vibrionaceae.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODA29344.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LYBM01000072; ODA29344.1; -; Genomic_DNA.
DR RefSeq; WP_068905569.1; NZ_LYBM01000072.1.
DR AlphaFoldDB; A0A1C3E7Z2; -.
DR STRING; 1080227.A8L45_22370; -.
DR OrthoDB; 5378341at2; -.
DR Proteomes; UP000094936; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.40; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000094936};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..845
FT /note="Peptidase M4 family protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008672858"
FT DOMAIN 68..107
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 254..400
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 403..547
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT REGION 212..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 393
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 475
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 845 AA; 93775 MW; C58FF7F874C6477E CRC64;
MKKGNGFTLS AIAGGITYGL LMASQAQAAE SITLNHVDLD NKGNVSLFSS TTPQSKIANA
LGLPADVGFT VKRTMKDARG NTHTRMQQTF QGIPVWNGEA ILHGTAQKNT LTGKVYTGFS
QSRHLMRLTS AQNVSQEVER FLNQKYGETG RKLIDLRAKM YVFVDENGKD QLVYHVDLIT
ETTPGTPSRP MLLLNASDLS VVKYWEGLAH SEEHQHDHQE NAGHEHHRHD QHGHDHQQLS
AWAQLLAKGP GGNTKTGRYV YGEDYESLTI TREGETCYLE SPNVRTVDME HKYDLSKDDA
FSFSCLDGEE PINNQREVNE AYSPLNDAFY FGNVSFNMYK DWYDTSPLPF QLMMKVHFGE
DFENAFWNGR FMTFGDGKDY FYPLVDINVA THEVSHGFTE FNSGLIYANE SGGMNEAFSD
ISAEGSEFYW KGDVDWIVGA DIFKAEGGLR YFEDPTEDGR SIGHYDDYYD GMNVHFSSGI
FNRAYYLLAN SSGWDPRKAL DVYVLANQAY WTADSTFEEG ACGVISSAYD LGYDWQVVFK
SFLEVGVVCT NTGVDTDYDG LDDGYEIKHG FNPFNSNDAQ KDFDNDGLSN LAEAGINTDP
KNADSDRDEL TDGDEDKLGY NLLSSDSDSD GIDDHFENEM GLNPLDSSDA LLDADNDGVI
NLTEYQGGSD LFDDMSIPAL GRGFLFDFEE GAVPEEWGAA AGPKVFEITG ENTIGNFSVV
SQEIDHNSTV FNYIVLNGQG GMLSFDVKTS TEEGYDFFEL AVDGDILYRA SGEKDYHRVE
VNVPEGSGVV TFSYTKDGGA IGGEDKVWLD NIQLETGYVD TDNDGMDDRW ERVNGLNSSD
PSDAC
//
