ID A0A1C3ESA8_9GAMM Unreviewed; 197 AA.
AC A0A1C3ESA8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000256|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000256|HAMAP-Rule:MF_00768};
GN ORFNames=A8L45_00500 {ECO:0000313|EMBL:ODA36119.1};
OS Veronia pacifica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Veronia.
OX NCBI_TaxID=1080227 {ECO:0000313|EMBL:ODA36119.1, ECO:0000313|Proteomes:UP000094936};
RN [1] {ECO:0000313|EMBL:ODA36119.1, ECO:0000313|Proteomes:UP000094936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAIM 1920 {ECO:0000313|EMBL:ODA36119.1,
RC ECO:0000313|Proteomes:UP000094936};
RA Gomez-Gil B., Enciso-Ibarra J.;
RT "Genomic Taxonomy of the Vibrionaceae.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Repressor involved in choline regulation of the bet genes.
CC {ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine. {ECO:0000256|ARBA:ARBA00024936}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation]. {ECO:0000256|ARBA:ARBA00004719,
CC ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODA36119.1}.
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DR EMBL; LYBM01000001; ODA36119.1; -; Genomic_DNA.
DR RefSeq; WP_068898097.1; NZ_LYBM01000001.1.
DR AlphaFoldDB; A0A1C3ESA8; -.
DR STRING; 1080227.A8L45_00500; -.
DR OrthoDB; 7618612at2; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000094936; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR NCBIfam; TIGR03384; betaine_BetI; 1.
DR PANTHER; PTHR30055:SF254; HTH-TYPE TRANSCRIPTIONAL REGULATOR BETI; 1.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00768, ECO:0000256|PROSITE-
KW ProRule:PRU00335}; Reference proteome {ECO:0000313|Proteomes:UP000094936};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00768};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00768};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00768}.
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00768,
FT ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 197 AA; 22085 MW; 382880F70D436AB4 CRC64;
MPKLGMPDIR RPQLVRATMA VIERVGLHSA SISLISKEAG VSTGIINHYF GGKEGLLEET
MREVLRQLSH SVKSRMAALP QDAHRERINA IVAGNFDGYQ TENKVAKTWL AFWTLSMHNK
KLKRLQRVNE MRLLSHLKRE LKALLPQSQA ELAAHSVAAL IDGIWLRGTL NPDGIDLDTA
KRIINDYLDM QLASSNK
//
