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Database: UniProt
Entry: A0A1C3K4Y2_9BURK
LinkDB: A0A1C3K4Y2_9BURK
Original site: A0A1C3K4Y2_9BURK 
ID   A0A1C3K4Y2_9BURK        Unreviewed;       188 AA.
AC   A0A1C3K4Y2;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Adenine phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011893, ECO:0000256|HAMAP-Rule:MF_00004};
DE            Short=APRT {ECO:0000256|HAMAP-Rule:MF_00004};
DE            EC=2.4.2.7 {ECO:0000256|ARBA:ARBA00011893, ECO:0000256|HAMAP-Rule:MF_00004};
GN   Name=apt {ECO:0000256|HAMAP-Rule:MF_00004};
GN   ORFNames=ODI_04315 {ECO:0000313|EMBL:SBT26542.1}, ODI_R0517
GN   {ECO:0000313|EMBL:SOE46881.1};
OS   Orrella dioscoreae.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Orrella.
OX   NCBI_TaxID=1851544 {ECO:0000313|EMBL:SBT26542.1, ECO:0000313|Proteomes:UP000078558};
RN   [1] {ECO:0000313|EMBL:SBT26542.1, ECO:0000313|Proteomes:UP000078558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Orrdi1 {ECO:0000313|EMBL:SBT26542.1};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SOE46881.1, ECO:0000313|Proteomes:UP000078558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Orrdi1 {ECO:0000313|EMBL:SOE46881.1};
RA   de Groot N.N.;
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes a salvage reaction resulting in the formation of
CC       AMP, that is energically less costly than de novo synthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00004}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00000868, ECO:0000256|HAMAP-
CC         Rule:MF_00004};
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC       from adenine: step 1/1. {ECO:0000256|ARBA:ARBA00004659,
CC       ECO:0000256|HAMAP-Rule:MF_00004}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC       Rule:MF_00004}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_00004}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000256|ARBA:ARBA00008391, ECO:0000256|HAMAP-
CC       Rule:MF_00004}.
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DR   EMBL; FLRC01000033; SBT26542.1; -; Genomic_DNA.
DR   EMBL; LT907988; SOE46881.1; -; Genomic_DNA.
DR   RefSeq; WP_067756429.1; NZ_LT907988.1.
DR   AlphaFoldDB; A0A1C3K4Y2; -.
DR   STRING; 1851544.ODI_04315; -.
DR   KEGG; odi:ODI_R0517; -.
DR   OrthoDB; 9803963at2; -.
DR   UniPathway; UPA00588; UER00646.
DR   Proteomes; UP000078558; Chromosome i.
DR   Proteomes; UP000078558; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003999; F:adenine phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006168; P:adenine salvage; IEA:UniProtKB-UniRule.
DR   GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_00004; Aden_phosphoribosyltr; 1.
DR   InterPro; IPR005764; Ade_phspho_trans.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   NCBIfam; TIGR01090; apt; 1.
DR   PANTHER; PTHR11776; ADENINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR11776:SF7; PRIBOSYLTRAN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00004};
KW   Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_00004,
KW   ECO:0000313|EMBL:SBT26542.1};
KW   Purine salvage {ECO:0000256|ARBA:ARBA00022726, ECO:0000256|HAMAP-
KW   Rule:MF_00004}; Reference proteome {ECO:0000313|Proteomes:UP000078558};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00004, ECO:0000313|EMBL:SBT26542.1}.
FT   DOMAIN          45..158
FT                   /note="Phosphoribosyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00156"
SQ   SEQUENCE   188 AA;  20450 MW;  2BF1417262BAE638 CRC64;
     MQNDLHDLVR RAIRSVPDWP KPGVTFRDIT PVLQDPRAFR VLIDLFVYRY MRQRLDLVAG
     IDARGFIVGS VLAYELNLGF VPVRKQGKLP SRTVSESYVL EYGNATVEMH ADAVRTGQRV
     LLVDDLIATG GTMLAGIKLL QRLGANVVEA AAVIDLPELG GSRAIAATGT PLYTVCQFGG
     ETEDAPAA
//
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