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Database: UniProt
Entry: A0A1C3K7W5_9BURK
LinkDB: A0A1C3K7W5_9BURK
Original site: A0A1C3K7W5_9BURK 
ID   A0A1C3K7W5_9BURK        Unreviewed;       435 AA.
AC   A0A1C3K7W5;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   10-APR-2019, entry version 15.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=ODI_00582 {ECO:0000313|EMBL:SBT27593.1}, ODI_R1600
GN   {ECO:0000313|EMBL:SOE48705.1};
OS   Orrella dioscoreae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Orrella.
OX   NCBI_TaxID=1851544 {ECO:0000313|EMBL:SBT27593.1, ECO:0000313|Proteomes:UP000078558};
RN   [1] {ECO:0000313|EMBL:SBT27593.1, ECO:0000313|Proteomes:UP000078558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Orrdi1 {ECO:0000313|EMBL:SBT27593.1};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SOE48705.1, ECO:0000313|Proteomes:UP000078558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Orrdi1 {ECO:0000313|EMBL:SOE48705.1};
RA   de Groot N.N.;
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FLRC01000055; SBT27593.1; -; Genomic_DNA.
DR   EMBL; LT907988; SOE48705.1; -; Genomic_DNA.
DR   RefSeq; WP_067759482.1; NZ_LT907988.1.
DR   EnsemblBacteria; SBT27593; SBT27593; ODI_00582.
DR   KEGG; odi:ODI_R1600; -.
DR   KO; K00003; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000078558; Chromosome i.
DR   Proteomes; UP000078558; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078558};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:SBT27593.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078558};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      355    430       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       9     16       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    205    205       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     105    105       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     190    190       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   435 AA;  46346 MW;  EF6BF319B74730AA CRC64;
     MKPIKVGLLG LGVVGGGTWK VLARNAEEIA RRAGRRIEVT RVAVRDVAKA RMRVGNEVEV
     AADPHAIVRD PSIDIVVELI GGDTLARELV LEAIANGKHV VTANKALLAK HGNEIFAAAS
     AQGVMVAFEA AVAGGIPIIK AIREGLTANR IEWVAGIING TTNFILSEMR SRGLPFAQVL
     AEAQRLGYAE ADPTFDIEGV DAAHKLTLLA SLAFGVPVQF ERAHVEGISN LAAEDIAHAA
     RLGYRIKLLG ITRRRADGIE LRVHPALVPA ERLLANVEGA MNAVLVRGDA VGPTLYYGQG
     AGEEPTASAV VADLVDVTRL HTADPGNRVP HLAFQPDAMS DTPILSIEDT ETSYYLRMRV
     EDRPGVLADI ARILSDASIS IGSMIQEPSS DGSGADIIFL THLARERNVN LAIASIEASP
     FVRSTVTRLR LENLT
//
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