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Database: UniProt
Entry: A0A1C3NBM6_9ACTN
LinkDB: A0A1C3NBM6_9ACTN
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ID   A0A1C3NBM6_9ACTN        Unreviewed;       361 AA.
AC   A0A1C3NBM6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   05-JUN-2019, entry version 13.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=GA0070620_5594 {ECO:0000313|EMBL:SBV30007.1};
OS   Micromonospora krabiensis.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Micromonospora.
OX   NCBI_TaxID=307121 {ECO:0000313|EMBL:SBV30007.1, ECO:0000313|Proteomes:UP000199393};
RN   [1] {ECO:0000313|Proteomes:UP000199393}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45344 {ECO:0000313|Proteomes:UP000199393};
RA   Varghese N., Submissions Spin;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; LT598496; SBV30007.1; -; Genomic_DNA.
DR   PATRIC; fig|307121.4.peg.5702; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000199393; Chromosome i.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199393};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199393};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       52    342       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   361 AA;  38303 MW;  833C8808E459D51C CRC64;
     MTTPETDRVS DQRIDRVVPL TTPALLHHEL PLDDTLASAV LAGRRAVGRV LDRADDRLLV
     VVGPCSVHDP AAALDYARRL RVAADRVADD LLVVMRVYFE KPRSTVGWKG LINDPGLDGS
     GDVNTGLRLA RALLLDVLRV GLPVGCEFLD PITPQYIADT VAWGAIGART VESQVHRQLA
     SGLSMPIGMK NRPDGSIGTA VDAIRAAGVP HVFPGIDVSG TPAIMHTRGN ADGHLVLRGG
     GGRPNYDAES VAGAIDLLRA AGLPERVVVD ASHANSGKDH RNQPVVADDV AAQLAAGQRG
     IVGIMLESFL QPGRQDLDPT RELEYGKSVT DACMGWDTTD EVLDRLAAAV RARRATLPTP
     A
//
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