ID A0A1C3NCD1_9ACTN Unreviewed; 629 AA.
AC A0A1C3NCD1;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=GA0070620_5802 {ECO:0000313|EMBL:SBV30209.1};
OS Micromonospora krabiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=307121 {ECO:0000313|EMBL:SBV30209.1, ECO:0000313|Proteomes:UP000199393};
RN [1] {ECO:0000313|Proteomes:UP000199393}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45344 {ECO:0000313|Proteomes:UP000199393};
RA Varghese N.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; LT598496; SBV30209.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C3NCD1; -.
DR STRING; 307121.GA0070620_5802; -.
DR PATRIC; fig|307121.4.peg.5907; -.
DR Proteomes; UP000199393; Chromosome i.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06568; GH20_SpHex_like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000199393}.
FT DOMAIN 77..210
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 214..530
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..599
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 378
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 629 AA; 66139 MW; 78167ED74C3E8DD3 CRC64;
MSTLPTPADR DATPTREPAV TGVDGVPPRE TAVAGDGVPL RETAVADLVR AADRAATELL
VPPAATLGHA AAARLGDVVP APEQVHPVPG ADHRLGPDTV IRVGADPAAR AVADQLAALL
RPATGYPLPV TDLADPESGG GITLTLTDDE ALGPEGYRLD VDRDAVRVTA GAPAGLLYAV
QTLRQLLPAA VESATPVPGP WILPGGSIVD RPRFPYRGAM LDVARHFFPV ADVLRVIDHL
VRYKLNHLHL HLTDDQGWRI AVDAWPRLTT VGGMGEVGDG PGGSYSTADY QRIVRYAADR
HVTVVPEIDL PGHTNAALVA YPELAPEGVD PPTPYTGTEV GFSYVDPASE RTYDFIADVL
GEVAAHTPGP WLHIGGDEAF KVKGEAYTGF VERVQRLVAA TGKTVVGWHQ IAPAAHAEGR
VLQWWGTTPD DPTTAEAVRR GARVIASPAN LIYLDMKYAP DTPIGHDWAG LIDVRRAYDW
DPGSHLTGVP AEAILGVEAP LWTESVTSLP EIEFMLFPRL PAVAELGWSP RSTHDWAGFR
ERLAGHAPRW TTAGITFHAA PEVPWPVAIG PGTAPAATIP TQPTGQAPPT APPIPAGDPI
PAGTTTRVEG PPGADGAISA DGAITPDEA
//
