ID A0A1C3NSS7_CAEEL Unreviewed; 369 AA.
AC A0A1C3NSS7;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=IRK_C domain-containing protein {ECO:0000313|EMBL:SBV53396.1};
GN Name=irk-3 {ECO:0000313|EMBL:SBV53396.1,
GN ECO:0000313|WormBase:K04G11.5d};
GN ORFNames=CELE_K04G11.5 {ECO:0000313|EMBL:SBV53396.1}, K04G11.5
GN {ECO:0000313|WormBase:K04G11.5d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:SBV53396.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:SBV53396.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:SBV53396.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR EMBL; BX284606; SBV53396.1; -; Genomic_DNA.
DR RefSeq; NP_001317903.1; NM_001330920.1.
DR AlphaFoldDB; A0A1C3NSS7; -.
DR SMR; A0A1C3NSS7; -.
DR EnsemblMetazoa; K04G11.5d.1; K04G11.5d.1; WBGene00002151.
DR GeneID; 191696; -.
DR AGR; WB:WBGene00002151; -.
DR WormBase; K04G11.5d; CE51731; WBGene00002151; irk-3.
DR OrthoDB; 4126787at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002151; Expressed in larva and 2 other cell types or tissues.
DR ExpressionAtlas; A0A1C3NSS7; baseline and differential.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR041647; IRK_C.
DR InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR InterPro; IPR040445; Kir_TM.
DR PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR11767:SF61; IRK_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; PF17655; IRK_C; 1.
DR PRINTS; PR01320; KIRCHANNEL.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003822};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU003822};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003822};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003822}.
FT TRANSMEM 73..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..174
FT /note="Potassium channel inwardly rectifying transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01007"
FT DOMAIN 181..349
FT /note="Inward rectifier potassium channel C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17655"
SQ SEQUENCE 369 AA; 42567 MW; E7439F57369E594A CRC64;
MSLAEELERL SGENGAKKEL NGWRLSSSAP ELGVQRARLV SKDGKTLLNN IQIPERFRQA
YKNWFHLIIE CNWRTICILF LLGFIVSWTI FAVIYYVISR LKTVKKDESC IANVDTLISA
FLFSMESQHT IGYGLRYMTD LCPPAYLTLC VQCVVGVFLQ TILAGIVIAK ILRPKKRRQE
MRFSRMAVIG PLDEHDKRPT LMIRLADIQE KLFLAESHVR LYMACSKINS RGDRELIGVK
DMNVGYDSGW DRVLLLWPII VRHVINEDSP LYGMSRENIV KADFELIMTV EGIVEATGMT
FQARTSFLPD EILWGYKFKP MVLMNEKLSK YEVHYSFFDQ TERVCDFDAQ TIETEETEDE
HHHNASGFL
//
