ID   A0A1C4BYW7_9ENTR        Unreviewed;       390 AA.
AC   A0A1C4BYW7;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Membrane fusion protein, multidrug efflux system {ECO:0000313|EMBL:SCC11923.1};
GN   ORFNames=GA0061070_100966 {ECO:0000313|EMBL:SCC11923.1};
OS   Kosakonia oryziphila.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Kosakonia.
OX   NCBI_TaxID=1005667 {ECO:0000313|EMBL:SCC11923.1, ECO:0000313|Proteomes:UP000198515};
RN   [1] {ECO:0000313|Proteomes:UP000198515}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=REICA_142 {ECO:0000313|Proteomes:UP000198515};
RA   Varghese N., Submissions Spin;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000256|ARBA:ARBA00009477}.
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DR   EMBL; FMBC01000009; SCC11923.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4BYW7; -.
DR   OrthoDB; 9811754at2; -.
DR   Proteomes; UP000198515; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR005694; MFP_proteobact.
DR   NCBIfam; TIGR00998; 8a0101; 1.
DR   PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR   PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        23..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..346
FT                   /note="Cation efflux system protein CusB"
FT                   /evidence="ECO:0000259|Pfam:PF00529"
FT   DOMAIN          205..289
FT                   /note="RND efflux pump membrane fusion protein barrel-
FT                   sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF16576"
SQ   SEQUENCE   390 AA;  42337 MW;  DD51FAC99135602B CRC64;
     MSANAENNPP QQPVKKRGKR KGALLMLTLL FIVIAVAYGI YWFLVLRHYE ETDDAYVAGN
     QVQIMAQVSG SVTKVWADNT DFVKQGDVLV TLDATDAQQA FEKAQTALAS SVRQTRQSMI
     NSKQLLASIE VKKTALAQAQ SDLNRRIPLG SANLIGREEL QHARDAVTSA QADLDVAIQQ
     YNANQAIVLD TPLEDQPAVK QAATEVRNSW LALQRTKIVS PITGYVSRRA VQPGAQISPT
     TALMAVVPAT NLWVDANFKE TQLAHMRIGQ TATVVSDIYG DEVTYSGKVV GLDMGTGSAF
     SLLPAQNATG NWIKVVQRLP VRVELDAKQL AEHPLRIGLS TLVKIDTADR EGQVLASQVR
     SSPAYESNAR EISLDPVNTL IENIVKANAG
//