ID A0A1C4I8E2_9ACTN Unreviewed; 739 AA.
AC A0A1C4I8E2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GA0115251_10386 {ECO:0000313|EMBL:SCD33155.1};
OS Streptomyces sp. TverLS-915.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839763 {ECO:0000313|EMBL:SCD33155.1, ECO:0000313|Proteomes:UP000198957};
RN [1] {ECO:0000313|EMBL:SCD33155.1, ECO:0000313|Proteomes:UP000198957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TverLS-915 {ECO:0000313|EMBL:SCD33155.1,
RC ECO:0000313|Proteomes:UP000198957};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FMCE01000032; SCD33155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4I8E2; -.
DR Proteomes; UP000198957; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198957}.
FT DOMAIN 22..302
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 303..559
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT DOMAIN 657..737
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 570..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 739 AA; 80621 MW; 9D6EE8BF9B7EF13F CRC64;
MTAAPQDSLF PPVPESADAV LHGLDPEQRE VALALTGPVC VLAGAGTGKT RALTHRIAYG
VRTGRYKPGT VLAVTFTQRA AGEMRGRLRE LGAHGVQART FHSAALRQLQ FFWPKVVQAE
PPRLVERKIQ LVVQAAEACG LRLDRAELRE VTGDIEWAKA TQTVPDDFAE AAAAAGRTTS
REALETARVY AQYEALKRAS GRIDFEDVLL LTIAILQDRE DIAQQVRSQY RHFTVDEYQD
VSPLQQRLLD LWLGERDDVC VVGDASQTIY SFTGATPEHL LGFPARHPGA TVVRLVRDYR
STPQIVHLAN NLLSHATGPA ARQRLELVAQ RPPGPVPEST EYADEVAEAE DVAHRIRALV
AEGVPAAHIA VLFRTNGQSN LYEQALGDAG VPYRLRGAEA FFDRPEIRSA LSAVRAAAHS
GANDTALDLA APLPAQLRRV LVSHRLWTAQ PPAGSGAVRE RWESLAALVR LAEELARARP
GAALTDLAAE LADRQANQHV PTVDGVTLAS LHAAKGLEWD AVFLVGLAEG MLPITYAQTE
EQVEEERRLF YVGITRARSR LHLSWSLSRT PGGWGGRKPS RFLDALRTPG SARPASDAPR
LRTGRAPATN GERHTHDRGA GERPVPRRRA PARCRVCGRT LTEAGEMKLM RCETCPSDMD
EGVYQRLRDW RGERAQDLGQ PDFCLFTDKT LVAIAEAVPE TEAELSRIPG VGARKFRRFG
SEVLAICAGQ ECAPGAKAD
//
