ID   A0A1C4IF65_9ACTN        Unreviewed;       292 AA.
AC   A0A1C4IF65;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Pyruvate dehydrogenase E2 component (Dihydrolipoamide acetyltransferase) {ECO:0000313|EMBL:SCD35563.1};
DE   Flags: Fragment;
GN   ORFNames=GA0115251_104829 {ECO:0000313|EMBL:SCD35563.1};
OS   Streptomyces sp. TverLS-915.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839763 {ECO:0000313|EMBL:SCD35563.1, ECO:0000313|Proteomes:UP000198957};
RN   [1] {ECO:0000313|EMBL:SCD35563.1, ECO:0000313|Proteomes:UP000198957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TverLS-915 {ECO:0000313|EMBL:SCD35563.1,
RC   ECO:0000313|Proteomes:UP000198957};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|ARBA:ARBA00001938};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317}.
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DR   EMBL; FMCE01000042; SCD35563.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4IF65; -.
DR   Proteomes; UP000198957; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR   PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:SCD35563.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198957};
KW   Transferase {ECO:0000313|EMBL:SCD35563.1}.
FT   DOMAIN          1..25
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:SCD35563.1"
SQ   SEQUENCE   292 AA;  30535 MW;  259A1ADACFD89CB8 CRC64;
     GVDLAAVVPS GPDGVITRED VHAAATSVRE PARQAPGQQP QESASQAPAE AAAPQADPSA
     RETRIPIKGV RKATAQAMVG SAFTAPHVTE FVTVDVTRTM KLVEKLKADP DMAGLRVNPL
     LLVARALLLA IRRNPEINAA WDEESQEIVV KHYVNLGIAA ATPRGLIVPN IKDADSLSLA
     GLSTALSDLV GTAREGRTSP AAMRGGTVTI TNVGVFGVDT GTPILNPGES AILAVGAIKP
     QPWVHKGKVK PRQVTTLALS FDHRLVDGEL GSKVLADIAA VLEQPKRLLT WG
//