ID A0A1C4KGR4_9ACTN Unreviewed; 1062 AA.
AC A0A1C4KGR4;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Enediyne polyketide synthase {ECO:0000313|EMBL:SCD60385.1};
DE Flags: Fragment;
GN ORFNames=GA0115251_114615 {ECO:0000313|EMBL:SCD60385.1};
OS Streptomyces sp. TverLS-915.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839763 {ECO:0000313|EMBL:SCD60385.1, ECO:0000313|Proteomes:UP000198957};
RN [1] {ECO:0000313|EMBL:SCD60385.1, ECO:0000313|Proteomes:UP000198957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TverLS-915 {ECO:0000313|EMBL:SCD60385.1,
RC ECO:0000313|Proteomes:UP000198957};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FMCE01000134; SCD60385.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4KGR4; -.
DR Proteomes; UP000198957; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198957};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..465
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 945..1021
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 911..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1062
FT /evidence="ECO:0000313|EMBL:SCD60385.1"
SQ SEQUENCE 1062 AA; 111558 MW; 1582342818261435 CRC64;
MTTEPERIAV VGIACRYPDA DSPEELWQNV LAGRRAFRRL PDERMRREDY YSPDPAAPDR
HYAQKAAVLE GFEFDRVKHR IAGSTFRSTD MTHWLALDTV GRALADAGYP EGKGLPSAGT
GVVIGNSLTG EFSRANLMRL RWPYVRRTVG AALREQGWED EQLAAFLGSL EDRYKSPFPP
IDEDSLAGGL ANTIAGRICN HFDLGGGGFT VDGACSSSLL SVATACDGLG AGHLDVAIAG
GVDLSIDPFE VIGFAKTGAL ATSEMRVYDR GSNGFWPGEG CGAVVLMRDA DARAQGRFRY
ATIAGWGYSS DGRGGITRPE AAGHRLALER AYHRAGFGLE TVPYLEGHGT GTAVGDSTEL
RAFSEARRAA DPEAPPAALT SVKGNLGHTK AAAGIAGLLK AVLTVRHQII PPATGHYDPH
PELTGERPAL RVPTEAEPWP EGASVRAGVS SMGFGGINAH VVVEHADGVR RTALPRSVVR
LVRSRQDCEL LLVDADDTDA LRERLAGLAA LAGRLSYAEL GDLAATLQAE LAGRPLHAAV
VASSPEQAEE RLLGLLHRVD GGADSLLEPA AGLFLGGRSA REPRIGFLFP GQGAGRRADG
GALRRRFAEV DDLYREHRLP ADGDQVATEV AQPRIVTASV AGLRVLDALG IEATAAAGHS
LGELTALHWG GAMDEAGLLR LAATRGRVMA RASDGGGTMA GIAAGPDDVA PLLAGEPVVI
AGYNSPQQTV VSGPAAVVER VCARATERGI TAQRINVSHA FHSPAVAPAA RAFAEELADE
EFQPLTRQVV STVTGGPLAE DADTAELLTR QVLAPVRFAE AVTEVARRSD LLLEVGPGRI
LSGLAAQTAD DPVLALDTDG TSLAGLLNAV AAAWTLGARV RLDELFRDRF TRPLPLDKEF
RFLANPCESA PDGELPAQEA RATAVAATPV PDASPAGERE PEQDADTLGV LLRLSAARAE
LPLSALTPET NPLDELHLSS ITVGQIMNEA ARELGIDAPA TTSAFATSTL RELAGLLDEL
SDTELPRETG RPDAVAGVAP WVRAFAVDLV EAGPPAAPSP AE
//
