ID A0A1C4LKI5_9ACTN Unreviewed; 430 AA.
AC A0A1C4LKI5;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=H+/Cl-antiporter ClcA {ECO:0000313|EMBL:SCD74224.1};
GN ORFNames=GA0115251_12171 {ECO:0000313|EMBL:SCD74224.1};
OS Streptomyces sp. TverLS-915.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839763 {ECO:0000313|EMBL:SCD74224.1, ECO:0000313|Proteomes:UP000198957};
RN [1] {ECO:0000313|EMBL:SCD74224.1, ECO:0000313|Proteomes:UP000198957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TverLS-915 {ECO:0000313|EMBL:SCD74224.1,
RC ECO:0000313|Proteomes:UP000198957};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FMCE01000202; SCD74224.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4LKI5; -.
DR Proteomes; UP000198957; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF9; ION-TRANSPORT PROTEIN YFEO-RELATED; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198957};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 430 AA; 43222 MW; 951641E403EE4DAB CRC64;
MPRFAPVLTP TARRLAPLTL PALVTGALAA CVLLGVSWVA ERLQGVWWGT VPEAPGVGRY
AAGWVVLVLT CTGVLTGLVV RYVPGHAGPD PATTGLVDAP LPLAVLPGLL LATVLSLAGG
VSLGPENPIT AVNVALVYAA GRRLSPRVPG ELWTGLAAAG TIGALFGTPV AAALVLTEML
TERPGPALWD RLYAPLLAGA AGALTMTLVA EPSFDLALPP YGEARWAHLL PALLICLAGA
VLGLCAVAAF PYAHGAFARL GHPVLVCGAG GLVLGGLGVL GGHLTLFKGL DEVKELSAHP
GHWSAGALAG MAVVRTAALL VAASSGFRGG RIFPAVFVGV ALGLSAHQLF PGAAPEAPAV
ACGVLGVLLA VTRQGWLSLF TAAVLVADTA VLPLLCLAAL PAWLLVTGRP PMRLGGPGPV
PEERGTAPVA
//
