ID   A0A1C4MPP7_9ACTN        Unreviewed;       517 AA.
AC   A0A1C4MPP7;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Nucleobase:cation symporter-2, NCS2 family {ECO:0000313|EMBL:SCD87902.1};
GN   ORFNames=GA0115251_12701 {ECO:0000313|EMBL:SCD87902.1};
OS   Streptomyces sp. TverLS-915.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839763 {ECO:0000313|EMBL:SCD87902.1, ECO:0000313|Proteomes:UP000198957};
RN   [1] {ECO:0000313|EMBL:SCD87902.1, ECO:0000313|Proteomes:UP000198957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TverLS-915 {ECO:0000313|EMBL:SCD87902.1,
RC   ECO:0000313|Proteomes:UP000198957};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; FMCE01000250; SCD87902.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4MPP7; -.
DR   Proteomes; UP000198957; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR017588; UacT-like.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   NCBIfam; NF037981; NCS2_1; 1.
DR   NCBIfam; TIGR03173; pbuX; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198957};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        27..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        115..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          445..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..481
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   517 AA;  52085 MW;  582C51253D338F19 CRC64;
     MPSAPPAAAR PAKAVHPVDE VPPPLQLFAF GLQHVLAMYA GAVAVPLIVG GAMKLPPADL
     AYLITADLLI SGIATLIQCV GVWRFGVRLP LMQGCTFAAV APMVLIGTGS GGLPAIYGAV
     IVAGLAMVLL APVFGRLLRF FPPLVTGTVI LVIGLSLMPV AGAWVAGGEG AKDVGAPKNL
     ALSLFVLLVV IGVQRFAPPF LSRIAVLVGI VVGVLVAIPF GFTDFGGVGD ADWAGISTPF
     HFGAPTFEAG AIVSLLIVSL VSMTETSGDI IAVGEMTGRR AEPGTLADGL RADGVSTVLG
     GVFNTFPYTA FAQNVGLVGM TRVRSRWVVA AAGGMLVLLG LLPKLGAVVA AVPAPVLGGA
     GLVMFGTVAA SGLRTLSEVD FKGNHNLTVV AVALAVGLLP VGVPTVYDRF PDWFQTVMHS
     GISAGCLTAL VLNLLFNHLP GGKGSPEDDG IPADEAAVSP VSPDSPESPA SPDPSTPPVP
     SASSAPSASS ADGLAEPVGL AGGGVEDVVE KPGEERV
//