ID   A0A1C4N073_9ACTN        Unreviewed;       335 AA.
AC   A0A1C4N073;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Nucleotidyltransferase/DNA polymerase involved in DNA repair {ECO:0000313|EMBL:SCD91468.1};
GN   ORFNames=GA0115234_1052327 {ECO:0000313|EMBL:SCD91468.1};
OS   Streptomyces sp. DvalAA-43.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839762 {ECO:0000313|EMBL:SCD91468.1, ECO:0000313|Proteomes:UP000199186};
RN   [1] {ECO:0000313|EMBL:SCD91468.1, ECO:0000313|Proteomes:UP000199186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DvalAA-43 {ECO:0000313|EMBL:SCD91468.1,
RC   ECO:0000313|Proteomes:UP000199186};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC       untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC       forks, which arise in vivo from mismatched or misaligned primer ends.
CC       These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC       exonuclease (proofreading) activity. May be involved in translesional
CC       synthesis, in conjunction with the beta clamp from PolIII.
CC       {ECO:0000256|ARBA:ARBA00025589}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
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DR   EMBL; FMBW01000040; SCD91468.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4N073; -.
DR   OrthoDB; 4317601at2; -.
DR   Proteomes; UP000199186; Unassembled WGS sequence.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:UniProt.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR   PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000313|EMBL:SCD91468.1}.
FT   DOMAIN          31..131
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
SQ   SEQUENCE   335 AA;  35515 MW;  41770249F5017360 CRC64;
     MRTAPQVPGI LYLRFRKAGG GLPDSAGYEG LLALLGALTP VVEAAPPDGA LADVRGALRY
     FGQDVKGLAS VIRIRALALH GVDCAIGAAE NPMLARMAAR RAAPGTTFVV PGGGAAEFLA
     DRSAAALDGV GAATARTLCG YGLDSVGRIA AAPLGTLQRI TGVRTGRELW ERAHGIDRTA
     VVPGAAARSI AAERSFPRDE LDRERQRRAL MSLTEELGAR MRGDGQVCRA LAVSVRYADR
     TGYATLTRSR TLREPTAHSA ALTALAYRIH DSFALQRARV RGIGLRAEGL TDRERATCQL
     SFDPVDERAR RIEAVADRLR AKYGPQAVMP GRLAA
//