ID   A0A1C4NA81_9ACTN        Unreviewed;       259 AA.
AC   A0A1C4NA81;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Metallo-beta-lactamase type 2 {ECO:0000256|ARBA:ARBA00017223};
DE            EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE   AltName: Full=B2 metallo-beta-lactamase {ECO:0000256|ARBA:ARBA00030107};
DE   AltName: Full=Metallo-beta-lactamase type II {ECO:0000256|ARBA:ARBA00033087};
GN   ORFNames=GA0115240_132512 {ECO:0000313|EMBL:SCD95206.1};
OS   Streptomyces sp. DvalAA-14.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839759 {ECO:0000313|EMBL:SCD95206.1, ECO:0000313|Proteomes:UP000199020};
RN   [1] {ECO:0000313|EMBL:SCD95206.1, ECO:0000313|Proteomes:UP000199020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DvalAA-14 {ECO:0000313|EMBL:SCD95206.1,
RC   ECO:0000313|Proteomes:UP000199020};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Class-B
CC       beta-lactamase family. {ECO:0000256|ARBA:ARBA00005250}.
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DR   EMBL; FMCH01000300; SCD95206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4NA81; -.
DR   Proteomes; UP000199020; Unassembled WGS sequence.
DR   CDD; cd16282; metallo-hydrolase-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR42951:SF20; BETA LACTAMASE; 1.
DR   PANTHER; PTHR42951; METALLO-BETA-LACTAMASE DOMAIN-CONTAINING; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199020};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          33..227
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   259 AA;  26866 MW;  8E53A1743580EB82 CRC64;
     MDFVESAQQP GAGSSVWEHL APGVARRRLP GLDVTVGLVV GSDAVLLIDT GATPRAGEEL
     RQQVAALTGR EVTHVVLTHG HFDHVFGTAA FTGAEVYGQA SLDGYLRRER EALRENAVEL
     GTDPLEAAQA AGALVLPGRP VHGELDLDLG ERPVRLVHPG PGHTGHDLVV VVPGASASDP
     AVVFCGDLVE ESGEPQAGAD AVPGAWAAAV DALLELGGET GRYVPGHGAV VDARFLRAQR
     DALAERFGGQ DPDPGVRPH
//