ID A0A1C4QIT3_9ACTN Unreviewed; 645 AA.
AC A0A1C4QIT3;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=GA0115240_144854 {ECO:0000313|EMBL:SCE22598.1};
OS Streptomyces sp. DvalAA-14.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1839759 {ECO:0000313|EMBL:SCE22598.1, ECO:0000313|Proteomes:UP000199020};
RN [1] {ECO:0000313|EMBL:SCE22598.1, ECO:0000313|Proteomes:UP000199020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DvalAA-14 {ECO:0000313|EMBL:SCE22598.1,
RC ECO:0000313|Proteomes:UP000199020};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FMCH01000413; SCE22598.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1C4QIT3; -.
DR OrthoDB; 3196263at2; -.
DR Proteomes; UP000199020; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199020}.
FT DOMAIN 11..336
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 645 AA; 70928 MW; 5775AF50CB236F0D CRC64;
MTLSPVLEDH PLTVEQQAVV NQPWDARVLV TAGAGAGKTH TLVRRLDALV ESGELEAGEI
LVLSFSRAAV RELTERTARR ASAARRVRAQ TFDAWAAALL ARAYPDTEWG TRSFDQRIVA
ATDAIDQGAV EIGEQGAPGH VVIDEVQDLV GVRREMVEAL LDRFQDNSGF TVVGDSAQAV
YGFQVADAEK RAQETGRFLD WIRASFGEDL IELHLGDNFR ARTEAVRVAL PFGADLQRLP
RDPADAAAKA ERIHADLRAL LRATPNFGRL DSEFVRGALC DYPGSTAVLC RDNGQALTIS
GQLADAQVPH TLQRSARDRS TPAWIEELLS ATAASTLNEE HFAELLVGID LPPGSTEESL
WRSVRKVARG ARGTVDVSAL HRALAERRLP DELTATPPLP LVVSTVHRAK GLEFDRVLVV
EPRPLKEPRQ VEKKKYDYDP AAEARLLYVA MTRARDDLYV LDAPVTWQIR KDSRLDRWYL
GGRSSWARNG VELLGDDVSH EQPPGAEDIQ ENAAELLIHL RKGVLPGDPV ELVLLHGIPI
AADQSPPYAV VVAGRQVGVV SERFRTDLSR MLRRNIRTEV TTWPPLITGL RIDCVESVAG
GTATTERAGL GSQGVWLAPR VCGLGRFRWY EGQSEATRPP REEQQ
//
