ID   A0A1C4SQK0_9ACTN        Unreviewed;       630 AA.
AC   A0A1C4SQK0;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Thiol-disulfide isomerase or thioredoxin {ECO:0000313|EMBL:SCE49468.1};
GN   ORFNames=GA0115234_1094371 {ECO:0000313|EMBL:SCE49468.1};
OS   Streptomyces sp. DvalAA-43.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839762 {ECO:0000313|EMBL:SCE49468.1, ECO:0000313|Proteomes:UP000199186};
RN   [1] {ECO:0000313|EMBL:SCE49468.1, ECO:0000313|Proteomes:UP000199186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DvalAA-43 {ECO:0000313|EMBL:SCE49468.1,
RC   ECO:0000313|Proteomes:UP000199186};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FMBW01000071; SCE49468.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1C4SQK0; -.
DR   Proteomes; UP000199186; Unassembled WGS sequence.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd14951; NHL-2_like; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF01436; NHL; 2.
DR   Pfam; PF13905; Thioredoxin_8; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:SCE49468.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          25..171
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
SQ   SEQUENCE   630 AA;  67830 MW;  4F4B7BEB1D072600 CRC64;
     MAHRFPEVPA ECVDATVMLT VGMATRARVR APELVGKGGW LNTGDQQYTL ADLRGRIVVL
     DFWTFCCVNC LHVLDELREL EEKHRDTLVI IGVHSPKFVH EAEHQAVVDA VERYGVHHPV
     LDDPELATWK QYAVRAWPTL VVIDPEGYVV AQHAGEGHAH AIEKLVEELE AEHAAKGTLR
     RGDGPYVAPE PVATHLRFPG KALLLPEGGF LVSDTTRHRL VELAPDGETV RRHIGTGERG
     FADGGPDEAR FSEPQGLAVL PDGRIAVADT VNHALRALDP ATGAVTTLAG TGRQWWQGSP
     TSGPAREVDL SSPWDIAWFA DRLWIAMAGV HQLWTYDPAT GTVRVAAGTT NEGLVDGKAD
     EAWFAQPSGL AASVDGERLW VADSETSALR YVEHEGDGFT VRTAVGTGLF DFGHRDGAAA
     QALFQHPLGV TALPDGSVAV CDTYNHALRR YEPGSGEVTT LATDLREPSD AVLVDGDLVV
     IESARHRLTR LRLPEEAVRV ADRAHRTRRA ATAIAPGTLR LDVVFQAPAG QKLDTRYGPS
     TRLLVSATPP ELLAGGAGPG TDLFRDLVLA EGITEGVLHV SAMAASCDDD PSNEYPACHV
     HQQDWGVPVR VGPDGTARLP LVLAGMDEQA
//