ID   A0A1C4TES7_9ACTN        Unreviewed;      3330 AA.
AC   A0A1C4TES7;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SCE57964.1};
GN   ORFNames=GA0115234_113389 {ECO:0000313|EMBL:SCE57964.1};
OS   Streptomyces sp. DvalAA-43.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1839762 {ECO:0000313|EMBL:SCE57964.1, ECO:0000313|Proteomes:UP000199186};
RN   [1] {ECO:0000313|EMBL:SCE57964.1, ECO:0000313|Proteomes:UP000199186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DvalAA-43 {ECO:0000313|EMBL:SCE57964.1,
RC   ECO:0000313|Proteomes:UP000199186};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; FMBW01000091; SCE57964.1; -; Genomic_DNA.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000199186; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 2.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          952..1026
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2418..2492
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3330 AA;  354638 MW;  F32FFE675DCAD952 CRC64;
     MSPASVPSDG LLTLTGAQSG IWNAQRLEPD SPYYVVGDVV EISGGEPIDT HALAEAVRAT
     TEEAETLRLR VYDTPDGPRQ AVSEAPVGLP EVVDVSGAAD PVAAAQALVE DERARTAEAC
     RGMVGRVLCS RTVIKLSDHE VWYTQLGHHL VFDGYTASML ARRTAARYTA LVRGTEVPRS
     TFGRFADLVA ADRAYRDSDR CAEDRAYWVE RFTPLPDLGD PGDPAAGLPG RTLTARAVVT
     PEETARLRAF ADRIGVTWGE ALIAGYAAFL HRVLGRTDVV FALPLMCRAG STELRTPAMA
     VNVLPLRVTV RAGDDLVELS RRVASAMREM RDHQRYRGED LPRDLAVPGA GALLHGRGIN
     LKAFDLALDF AGAAGVMRNV AGGPPEDMGL SVLPTRDGGL LLGFEVDARA KDQAAVDSLL
     SGLRALLSGL TDGLSVGRIA LTGDAAGVPA GWCPPALPGT PVDVPTAFDT MAAAGPGHTA
     LVCGDDRLSA AELAARVHRV ARALRARGIG ADDVVALALP RSADSVVALL AVLDAGAAFL
     PLDAVHPPER LRELIDDTRP ELVLTAGAVD GLPWDTLLGE AAGLSGTPLT AGELSAPRHP
     EHLAYVIHTS GSTGRPKGVL GRAGGLAALL HHQRSTVVAE AERATGRRLR AAHTYSFAFD
     SAFDHLVWLL CGHELHVYDT ETARDADALL AAYARDGIDI VDTTPSMASP LVDAGLLDRR
     PALLVLGGEA TPPALWRRIA DSGITARNMY GPTEATVDST TARIDGGEPT IGHPLAGTRI
     HLLDSALQPV PHGAVGELYL AGPHLARGYL GRPGATAERF VADPFGAPGE RMYRTGDLAR
     WVPGRGLEYR GRGDGQVKIR GHRVETGEVE AALAAVPGVI AAAAAVRSSR LVGYIVSPSV
     TGEEARAHLA GRLPDHMVPG AVVVLDRLPV TPNGKLDRAA LPAPALPGGG REPRTERERL
     LCAVLAEALD VERVGVDDDF YALGGDSITA ITVSSRLRAA GLGLRPRDLL ARRSFAALAA
     SAELPADAPE PVDDPVGPVP APPIVRGLLD PHPDVDVVAG YAQWTALRVD GLGHDDLVTG
     VQAVLDHHDA LRLRAADGLE TLPRGVVRAV VGEFRGEDVT ALARRLAGEL DPRSGDLLRA
     ALLRTDDGTP DRLVVVVHHL AMDGVSWRIL LPDLHTACTG GTLAPVGASW RRHAVLLAGQ
     GESGARRGEL DHWRTALGAA SRLGARPLDP ARDTVATAHR SVTMASAEAT EALLTTLPAA
     YRAGVDEVLL AALVLALRGW GLRGDAVTVS MEGHGREHLD LARTIGWFTS EYPVRVPASE
     DVGQALRAAK EARRAVPDGG VGYGVLRHLD PEAGPELAAT PPPDVLLNYL GRFAPLAGTG
     WHLPEHDAFS VTEPDAKALE QVLALNCFVH EQDEPRLAVE WTAATGVLGT DAVAALQQSW
     AAALDALAAH ALHTEGGLTP SDLPLVGLDQ AAIDVLERTG RIADVLPATP LQVGLSFHTL
     VRDDHDTDVY VVQAVTTLAG ELEPARMAEA AHELLRRHPA LRVHLATVGD DVVQVIPADI
     ALDWRQDDRF PEAARADLER PFDPARPPLI RFLLSRVGPA EHKLVITNHH ALLDGWSMPL
     VGRTLLAIYA ELSGGPAAPA APRLSEYFRW LAGRDQEASL AAWRDALAGV DDATRLAPAS
     TGTGVERPGR ETVALGREFS DRLRAFARER GVTLTTVLQT AWGLLLGRLT GRRDVVFGCP
     VSGRPAEVDG VESMIGQLGT TIPVRVRHTQ DQSALELMAQ VHAESVLLAE HHHVGLPGIQ
     RAVGVGELFD TMLVMENFPL SSRKRTPLAP GLDLAGVDIT DATHYALTVI VIPDEEITIG
     LGYQPRAFTA ATVRDYGRWL HNLLREIVDD PARPAIRLPA LDADERARML RTGTGAVPAR
     ARGHWLEEFA AWVHRKPDAE ALVCRDRSLG YAELDRRANQ VAHALIARGV RPQDPVAVLL
     GRDIEMTVAL FGVAKAGAVY VPMDTSYPRE RLAYMVDDIA PAAAVTTGAD LPVDRDIPVL
     RLDDPAVLAS VPDTDPAEAR AALTEDALAY VIYTSGTTGR PKGVGVTHRG VPDLIALQEE
     VVGVTEHDRY LHFASTGFDV AFWQTMVPLL SGGTSVIAPE EVRVPGDELL DYIIEHRVTG
     VNLLPSFLAA MPDDRTVGPD VFFVVGAERL DPELARRWGR GRRALFNAYG PTEVTINSTT
     WHYDPDDAGP LPIGRPDPHV RAYVLDGGLQ PVGVGVTGEL YLGGPSLARG YLGRPALTAA
     AFVADPFGPP GERMYRTGDL VRWRPDGQLV FLGRADHQIK VRGFRVELGE IESALTGHPD
     VRACAVITRE GRLVGYVIPA DGADLDTARV RAYLAGQLPD HMVPTALVPI DRLPLTPGGK
     LDSAALPDPG TAAAARREPA TEAETVLLGV FRDILGTDDI GPDDSFFDIG GDSIVSLQLV
     SRVRRRGLGL TPKDVFEGET VAGIAARARA LDGAAAPAVG DAPLTPVMRD LLRRSGAAAD
     GFCQWVEICV PPGGDETSWQ AVLDELLARH DVLRAHLADD LLRIPPVGAV SGADVLTGVR
     AGGDLRSAVD SGIAAAREAM DPRTGPVLRA VWVDAGPDRP GRLVLVAHHL VVDGVSWRVL
     LDDLEHAHSG GTLTRHGQSF LGWACSLRDA DRRAELPHWR RMSATPALTR PLDPARDTVA
     TATHHEIVLD AESTRALITT LPAAHRTTPD AVLLTALAQA VRAWRGTPEV LVALESHGRP
     REVDLSQTVG WFTAVHPVRL DAGDDVTAVR ERLRAQGDGL GHGILTAAGL LDPVEPEIAW
     NYLGQYPGAP DRETPWQTPP DADPLGSGGS DAMPLPYGLM VNALVRDDAL GIRITWPSAL
     FTAAGIEDLA GHLRTALLRI AAAPEIGALD RDRPVAGVQP LTPLQEVMLR HSRTERPDPY
     TVQSTFSLAG RLDTDALRAA GDDLLARHPN LGAVFPASLA VIPVSPRPDF RVCDGPDLLV
     CDGPADELLA ADLAEPFDPA RGPLLRLTVI RRGPDRADLV LTSHHVLSDG WSAPRILTEL
     FALYTARVRG RAPELPAPVP FADYLSWCAE HEPDLGAWAA ELDGLPEGDH LGGGDPGPAW
     QEPEVIAFDA ALVAGLTRLA AGRGLTRNTL VQGAWAVLLA RRSGRADVCF GAMVSCRPPA
     LEGVEEIIGL LANTVPVRAR LDGTLADTLT ALQSRQRALA EHHHVALSDL ERLTGRRRLF
     DSLVVFENYP VDPDRLREPA PGLTVVGTRF RESTHHPATL TVMPDGDGWT GVLAHRAGTD
     VDGLAEELLD LLRTLDKHLD NDVRDLLESR
//